. Amorolfine belongs to a group of medicines called topical antifungals . It is used to treat topical fungal infections topically. It inhibits the synthesis of ergosterol (component substance of the fungus cell wall) and thus, alters the permeability of the cell membrane and with it the growth of the fungus. It has an important antifungal activity against: dermatophytes, yeasts and molds.

What is it for

Topical therapy for onychomycosis (disease of the nails of the fingers and toes) caused by dermatophytes, yeasts and molds.

How is it used

There are commercialized topical forms of administration (solution). The appropriate dose of amorolfine may be different for each patient. Below are the most frequently recommended average doses, but if your doctor has prescribed a different dose, do not change it without consulting him or your pharmacist:


Amorolfine-based nail solution should not be used in patients who have developed treatment hypersensitivity. Given that there is still insufficient clinical experience with the pediatric use of amorolfine, the treatment is contraindicated in patients younger than 16 years. Amorolfine is exclusively for topical use. Avoid contact with eyes and mucous membranes. In treatment patients, who usually work with organic solvents, protection of the hands with waterproof gloves is recommended. The diagnosis of the disease must be confirmed both by direct microscopic examination, in potassium hydroxide solution, or by culture in an appropriate medium. The treatment should be continued without interruption until the nail has regenerated and the affected areas are healed. The required duration of treatment will basically depend on the severity and location of the infection. Typically, it will be six months on fingernails and nine to twelve months on toenails. A review of treatment every three months is recommended.

It can be used during pregnancy or breastfeeding

Although absorption after topical application is low, since the treatment is prolonged, it should not be used during pregnancy. Due to the low systemic absorption of this drug (topical application) it is not expected to pass into breast milk, however, since the treatment is prolonged, its use in nursing mothers is not recommended.

Dosage and method of administration

Apply once or twice a week to infected fingernails or toenails. The patient should use the solution as follows:

It is essential that before the first application, the diseased parts of the nail, especially the surface of the nail, are filed as well as possible with the files included in the package. Subsequently, the surface must be cleaned and degreased with the cleaning wipes, included in the container.

Before a new application, the affected nails must be filed down again and, in any case, they must be cleaned with the wipe in order to eliminate any possible remaining solution.

With one of the reusable spatulas supplied in the package, the solution will be spread over the entire surface of the nail and allowed to dry for 3 to 5 minutes. For each nail, these steps will be repeated. When removing the spatula from the bottle, care will be taken not to drip the solution down the neck of the bottle. The bottle should be tightly closed immediately after use. After using the spatula, clean the spatula and the neck of the bottle with the nail cleaning pad.

How it is preserved

Keep in a cool, moisture-free place, away from heat sources and direct light. Keep out of reach of children.


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