The Cisplatin is an alkylating agent. It works by modifying DNA by preventing replication and transcription in RNA and can cause mutations within it.
What is Cisplatin used for?
It is used as chemotherapy for different types of tumors, from carcinomas to sarcomas, passing through lymphomas and germ cell tumors. Among the malignancies against which it is most often used are: head and neck cancers , testicular cancer , bladder cancer , cervical cancer and non-small cell lung cancer.
How is Cisplatin taken?
It is administered intravenously via an IV or a device that allows it to be injected directly into a blood vessel in the chest and which is left in place throughout the course of treatment.
Therapy usually involves multiple courses of treatment with a variable cadence depending on the case.
Side effects of Cisplatin
Its possible side effects include:
- loss of taste or metallic taste in the mouth
- loss of fertility
- decreased appetite
- hearing problems (especially with higher pitched sounds)
- tiredness and breathlessness
- sense of fatigue
- increased risk of infections
- kidney damage
- numbness or tingling in the fingers
- fogging of vision
It is important to seek medical attention immediately in case of:
- redness of the face
- sudden need to urinate
- skin rashes
- feeling of warmth
- shortness of breath
Contraindications and warnings of Cisplatin
It can harm an unborn baby; it is therefore essential not to become pregnant during therapy.During chemotherapy and in the following 6 months it is also necessary to avoid vaccinations with live vaccines and it is good not to come into contact with subjects who have undergone this type of vaccinations.
Before treatment it is good to inform the doctor:
- about the presence of any drug allergies
- medicines, phytotherapy and supplements already taken in the past
- in the case of pregnant women or breastfeeding women