What is cisapride used for?

The cisapride is a drug that acts by stimulating the receptors of the nervous system related to the digestive system.It promotes the release of the neurotransmitter acetylcholine ,The result is a fast emptying of the stomach and intestinal transit.

What is cisapride used for?

It is used to treat the symptoms of gastric reflux, especially when it occurs with nocturnal burns resistant to other treatments.

How is cisapride taken?

It is administered orally in the form of tablets or liquid solution. Usually the dosage is 4 doses per day, to be taken 15 minutes before meals and before bedtime.

Side effects of cisapride

Its intake has been associated with the appearance of serious side effects – sometimes fatal – on the heart. In particular, the drug can cause:

  • arrhythmias, especially in the presence of previous predisposing disorders, for example ventricular arrhythmias,
  • respiratory failure and incorrect electrolyte imbalances,
  • kidney failure,
  • congestive heart failure,
  • prolonged lengthening of the QT tract,
  • ischemic heart disease
  • tachycardia
  • torsades de pointes
  • ventricular fibrillations
  • extension of the QT tract

The risks are greater in subjects taking other drugs that can prolong the QT tract, inhibit cytochrome P450 or reduce serum electrolytes.

It is recommended to seek immediate medical attention in cases where taking this medicine is associated with chest pain or vision problems.

Other potential side effects of the active substance include:

  • stuffy nose
  • stomach problems
  • cough
  • constipation
  • discharge of diarrhea
  • headache

Contraindications and warnings

On 14/07/00, the manufacturer voluntarily withdrew cisapride-based drugs from the U.S. trade because of their serious side effects. In Europe, the marketing of the related active substance has been suspended in both Germany and the United Kingdom. The Department for the Evaluation of Medicines and Pharmacovigilance of the Ministry of Health has restricted the indications for its use only to cases of gastroparesis (in adults) and gastroesophageal reflux disease (in early childhood).

The drug can generate drowsiness : it is therefore necessary to pay due attention in its use and not to take it before driving or operating dangerous machinery. It should also be remembered that alcohol can increase the sleepiness caused by this active ingredient.

Before taking cisapride, you should inform your doctor :

  • about the presence of any allergies to it or other drugs
  • medicines, phytotherapics and supplements already taken or that you are taking (remembering to mention diuretics, azithromycin, cimetidine, dirithromycin, miconazole, tranquilizers, vitamins, anxiolytics, anticholinergics and anticoagulants)
  • if you suffer (or have suffered previously) from intestinal problems or bleeding ulcers.
  • if you are pregnant or breastfeeding.

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