The Ceftadizima is an antibiotic belonging to the group of third-generation cephalosporins, with antimicrobial activity very similar to that of Cefotaxime against Gram-positive bacteria and enterobacteriaceae.
Explains its action by inhibiting the synthesis of the bacterial wall: like other cephalosporins, this antibiotic has the ability to bind to the transpeptidase enzymes that are necessary in order to create the bonds between the peptidoglycan chains (the polymer indispensable for the formation of the bacterial wall ): inhibition of transpeptidase activities compromises the stability of the bacterial wall, causing the death of growing bacterial cells.
What is Ceftazidima used for?
It is used to treat the following cephalosporin-sensitive infections in adults, children and infants:
- urinary tract infections ;
- skin, soft tissue, bone and joint infections;
- respiratory tract infections such as pneumonia;
- lung infections in patients with cystic fibrosis;
- ear infections;
- peritonitis ;
How is Ceftazidima administered?
It is marketed in the form of powder and solvent for solution for injection for intramuscular use, for intravenous use and for infusion.
Side effects of Ceftazidime
The recognized side effects are manifold, although it turns out to be a largely well tolerated antibiotic:
- headache ;
- dizziness ;
- paresthesias ;
Alterations in one or more liver and kidney function parameters;
Disorders at the site of drug inoculation (phlebitis or thrombophlebitis following intravenous administration; pain and / or inflammation following intramuscular administration);
- maculopapular or urticarioid rash:
- more rare angioedema and anaphylactic reactions (including bronchospasm and / or hypotension).
- discharge of diarrhea ;
- feeling sick ;
- abdominal pain;
- rarer colitis and candidiasis of the oral cavity;
- (rare) leukopenia ;
Contraindications and warnings of Ceftazidime
The limited amount of data about its use during pregnancy does not show any direct or indirect harmful effects on this delicate phase, on embryo / fetal development, on delivery or on post-natal development: since, however, at present, the amount of data is still modest, the use of this antibiotic should only be prescribed to pregnant women if the benefit outweighs the risk .
It is excreted in breast milk in small quantities which are not therapeutically relevant: it can therefore be used during breastfeeding.No studies on interference with the ability to drive and use machines have been performed. However, it should be borne in mind that the use of the drug can cause dizziness .In the administration of this medicinal product, it should be borne in mind that contextual treatment with high doses of cephalosporins and other nephrotoxic medicinal products can cause a negative effect on renal function .