Senna / Senna ( Senna, ) or a drug that is commonly known by the trade name Line Casino Prescott / Seno neck ( Senokot ) is a substance Zen Techno Side (Sennosides) prepared from the leaves and pods of Senna. (Senna alexandrina Mill) stimulate the intestinal peristalsis occurs (stimulant laxatives) as well as castor oil (castor oil) and drug Ibiza Coast Adil (Bisacodyl), but there are advantages. It is a natural substance with few side effects. It is commonly used as a laxative. (Medicine for constipation) for a short time [1]
In our home we can find this drug in the form of an extract that is then made into tablets or capsules. Or produce a liquid medicine for children Or as a drug in the form of brewed tea Using senna leaves instead of tea leaves For Thailand, both modern drugs are registered. (Extract form) and traditional medicine (brewed tea form) as an alternative for people to use the product. Which can be purchased at any drugstore It is also used in many hospitals. However, the correct and safe use of sennosides Always consult a doctor or pharmacist. And patients should stop taking the drug once the excretory system returns to normal [4].
Example of sennoside
Zen medications online site or drugs Senna (generic name) is a trade name such as emu Lax Senna (Emulax Senna), Seno AC / AC Line Casino (Senokot) etc.
Drug form of sennoside
- Tablets typically in 1 tablet contains 7.5 mg of Zen Technology website [1].
- 7.5 mg / 5 ml (1 teaspoon) syrup
IMAGE SOURCE: www.brandbuffet.in.th, www.clearchemist.co.uk
IMAGE SOURCE: twitter.com (@Namkwann) Senokot (Senokot) 10 tablets, about 35 baht, 12 large boxes (60 tablets total) about 90-100 baht.
Properties of drug Zennoside
- Used as a laxative (Constipation medicine) Treat constipation in a short time [1], [3], [4].
- This medication may be used for bowel preparation or bowel excretion prior to surgery or laparoscopy [3], [6].
- Sennosides may also be used to treat a number of other diseases or conditions, if in doubt ask your doctor or pharmacist [3].
Mechanism of action of sennoside
After taking the drug Sennoside The drug is structured by bacteria in the gut and gets a substance, Rheinanthrone This substance will help the intestines to compress or move more. Resulting in a feeling of urge to have a bowel movement This process takes place approximately 6-12 hours after taking the drug [1], [4].
Pharmacokinetics of sennosides
This drug is only partially absorbed. And is excreted in urine and feces Medicines can pass through the milk. But no adverse reactions in the infant were observed [6].
Before using sennoside
When prescribing all drugs, including sennosides Here are some things to tell your doctor or pharmacist:
- History of allergy to any drug Especially sennoside drugs or senna laxatives Including symptoms from such drug allergy, such as taking the drug, increased nausea, rash or tightness, difficulty breathing / difficulty breathing
- Various underlying diseases and prescription and over-the-counter medications Including dietary supplements, vitamins, and various herbal drugs that are currently or are currently being used. Because sennosides may exacerbate the symptoms of the underlying condition. Or drug interactions with other drugs and / or other pre-ingested supplements such as
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- The combination of sennosides with antidepressants or antipsychotic drugs such as Fluoxetine, Perphenazine, can cause certain electrolytes in the body. slump And followed by symptoms such as nausea, vomiting, dizziness, weakness, fainting, muscle pain, cramps, confusion, arrhythmia, etc. [4]
- The use of sennosides with certain antibiotics, such as azitromycin. (Azithromycin), Cyprofloxacin (Ciprofloxacin), Eritomycin (Erythromycin), sparfoxazin (Sparfloxacin) may increase the risk of decreased levels of magnesium and potassium in the body. And it brings these symptoms such as nausea, vomiting, dizziness, weakness, fatigue, drowsiness, fainting, confusion, muscle pain, cramps, etc. [4]
- Use of sennosides with steroid anti-inflammatory drugs such as hydrocortisone (Hydrocortisone), Prednisolone (Prednisolone), Triamcinolone. (Triamcinolone) may be at risk of dehydration and mineral salts. Especially potassium salt Causing muscle weakness Abdominal cramps, confusion, nausea, vomiting, dry mouth, thirst, difficulty breathing and swallowing, chest pain, arrhythmia, swollen legs [4]
- Combination of zenosides with anti-edema drugs such as chlorothiazide. (Chlorothiazide), Hydrochlorothiazide (Hydrochlorothiazide), Furosemide (Furosemide) may cause dehydration and mineral salts. It causes these symptoms such as arrhythmia. Dizziness, dry mouth, weakness, cramping, less urination. Kidney failure, seizures [4]
- Having or have had appendicitis Intestinal obstruction, abdominal pain (eg due to stomach or intestinal ulcers) [3]
- If it’s a lady Should report that there is a pregnancy Or are planning a pregnancy Or are breastfeeding Because many drugs can pass through the placenta or milk and enter the baby, they can cause adverse effects [3], [4].
Contraindications / precautions for use of sennosides
- Do not use this drug in patients with nausea and vomiting, intestinal obstruction, unexplained abdominal pain, gastric or intestinal ulcers, appendicitis [4], [6].
- Do not use this medication in children younger than 2 years [3].
- Do not use this drug in pregnant women during the first trimester (first 3 months) [4]
- Do not use any aging or expired medication [4].
- This drug should be used with caution in patients with chronic enteritis. (Inflammatory bowel disease (IBD)
- Should be careful about the occurrence of dehydration and mineral salts. Because this drug has a laxative effect [4]
- Long-term use of this drug You should be careful about inflammation of the intestinal tract [4].
- Should be careful about drug addiction sennosides. And should practice natural excretion [4]
- For patients with kidney disease Although with short-term use of sennoside, there have been no reports of nephrotoxicity from this drug. However, the drug should be avoided in patients with impaired renal function. This is because the drug is eliminated through the kidneys and may accumulate. Therefore, patients with symptomatic kidney disease may consider the use of laxatives that increase intestinal fiber. (Bulk-forming laxative) instead [6].
How to use sennoside
- For use in treating acute constipation.
- Adults and children over 12 years: 2-4 tablets (15-30 mg) once a day at bedtime [1], [4] (preferably start 2 tablets at a time if constipation is not good. Increase it to 4 tablets at a time, once a day before bedtime [2] ).
- Children aged 6-12 years aregiven 1-2 tablets (7.5-15 mg) once a day at bedtime or in the morning [4], [6].
- Children aged 2-6are given 3.75-7.5 mg of the drug once a day in the morning [6].
- Senna tablets may be used by the Government Pharmaceutical Organization. Or use about 1-2 handfuls (3-10 grams) of dried senna leaves and pods, or use 4-5 pods to be boiled with drinking water. You can also grind it into a powder, brew it with drinking water as a laxative.
- For use for bowel excretion before surgery, colonoscopy (Colonoscopy), the garden barium powder (Barium enema) recommended size is 105-157.5 mg (Liquid preparation) on the day before surgery . [6]
Instructions for use of sennoside
- Sennoside is usually taken once a day, in the evening or at bedtime. (To take the drug along with a glass of water) for the drug to release in the morning. Because this drug works about 6-12 hours after taking it, or patients can take the drug at the time that they want to be taken. (Either before or after meals) [1], [3], [4]
- Sennoside should only be taken with acute constipation. And should take the drug in a short time is not more than 7 days because taking this drug for a long time. May cause intestinal disorders Causes dependency on laxatives (Laxative dependency) as a result when stopping taking the drug The body will not be able to excrete on its own normally. Causing constipation even more It also causes damage to the nerves and muscles in the intestines. It was also found that the minerals in the body are disturbed, that is, the potassium levels And low calcium) [2], [5]
- Patients should practice natural bowel movements and stop taking drugs to prevent drug addiction [4].
- This medication should be used exactly as directed on the label or as directed by your doctor. Do not use less or more of the medication than indicated. If in doubt, ask your doctor or pharmacist [3].
- In case of long-term use of sennoside It should be under the supervision of a physician [3].
- The use of sennoside in children between the ages of 2 and 12 should be under the supervision of a physician. Especially in children aged 2-6 years [3].
- For those who suffer from frequent constipation Drinking enough water, about 8-10 glasses (2,000 ml) a day, and focusing on eating foods rich in fiber is a good and safe way to reduce constipation. But if following the above method still does not work Bulk forming laxative laxatives can be taken, such as laxatives containing basil, Ispaghula husk, Psyllium seed husk. ) Etc. (can be purchased at a pharmacy) because this drug is safer than the intestinal stimulant laxative to squeeze the sample sennoside. When having to eat continuously for a long time [2]
How do i store sennoside?
- Keep this medication in the original container it came in, tightly closed, and kept out of the reach of children and pets.
- This drug should be stored at room temperature. Keep the drug away from direct sunlight and heat. Keep the medication away from hot temperatures above 30 ° C and do not store the medication in wet or humid areas (such as in the bathroom, freezer of the refrigerator), as heat or humidity can cause deterioration of the drug.
- Discard any drug that is worn out or has expired.
When you forget to take Sennoside
If you forget to take Sennoside To take the medicine as soon as possible But if it is close to the next meal You can skip taking the next pill straight away. Without increasing the dose twice or more than usual
Side effects of drugs sennoside
- Long-term, high-dose use of this drug can cause severe abdominal pain or diarrhea, leading to dehydration and electrolysis. Especially potassium This results in muscle weakness and irregular heartbeat [1], [6].
- May cause discolored urine, dark urine, red urine (Which is not dangerous in any way [1] ), the intestines are black, the symptoms of the thumb / fingers (clubbing finger), disturb the balance of minerals in the body. (Especially potassium), bowel movement, colon work less / caused by laxative dependency (Laxative dependency), flatulence, abdominal discomfort Or a cramp in the lower abdomen [1], [3], [4], [6] The side effects that require immediate medical or pharmacist notice are nausea, vomiting, diarrhea, muscle weakness. Abnormal weight loss [3]
- Can cause hepatitis and liver failure. Acute liver failure and renal insufficiency were reported in a 52-year-old female patient who took a senna laxative powder for more than 3 years for a consecutive period. Supportive treatment, the patient’s condition improved and recovered. [6]
