Mesa Fe Dynamic Acid / a defenseman dynamic acid or acid’s effects Dynamic / acid’s effect was Mick ( mefenamic Acid ) or medications that people generally known that trade Fe Dynamic ( Fenamic ). , blue ( MEFA ), a fast-cooked ( Mefamed ), Aimee Stephen Starr ( Mefenstar ), Paul Stanton ( Ponstan ) is a drug painkillers such a crusade (NSAIDs), which are anti-inflammatory drugs. Non-steroid It is commonly used as a pain reliever for mild to moderate symptoms for a variety of causes, including menstrual pain [1].
Example of mephenamic
Mephenamic acidFemen, Femenstan 500, Femenstan 500, Fenamic 250, Fenmic, Fennic, Fespa 250, Fespa 500 (Fespa 500), Fevek, Fevest, Fevic 500 (Fevic 500), Gynogesic, Gynogesic, Gynogesic-500 (Gynogesic-500), Hypomic 500 (Hypomic 500), JV mic 500 (JV mic 500), Locpan, Magesic capsules, Substitute 250 (Matan 250). , Instead of 500 (Matan 500), Manic (Manic), Manomic, Masafen, Med-fenamic tablets (Med-fenamic tablets), Medilan capsules. (Mednil capsules), Mefa 500 (Mefa 500), Mefagesic, Mefamed, Mefamed 500, Mefamic, Mefec ), Mefen capsules, Mefen forte tablets, Mefenac 250 (Mefenac 250), Mefenac 500 (Mefenac 500), Mefenac 500. Namic 500 (Mefenamic 500), Mefenstar (Mefenstar),
Mephenamic dosage forms
- 250 mg capsule
- 500 mg tablet
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IMAGE SOURCE: pantip.com (by member number 2787599) Ponstan 500 (Ponstan 500) 1 pack of 10 tablets, price about 46-50 baht.
Properties of mephenamic
- It is used as a pain reliever for mild to moderate symptoms for a variety of causes [1], [3] such as headache, toothache, muscle pain, bone pain, traumatic pain, postoperative pain. Sciatica [5], [6] pain from certain arthritis such as Rheumatoid arthritis, Osteoarthritis, etc. [3], [4]. , [6]
- Used to relieve menstrual cramps. (Dysmenorrhea) before menstruation or during menstruation [1], [3], [5] It also relieves pre-menstrual disorders. Menstruation comes out excessively. This may come from the birth control IUD, sterilization, heavy menstrual discharge and an unknown cause. (Dysfunctional uterine bleeding – DUB) [6]
- Used as a fever reducer [4]
- This drug may also be used to treat other diseases or conditions, and if in doubt, consult your doctor or pharmacist [3].
Mechanism of action of mephenamic
Non-steroidal anti-inflammatory drugs (NSAIDs), including mephenamic acid. Is a drug that inhibits the production of protaglandin (Prostaglandin) in the body, which is the lead to inflammation. By interrupting the activity of the enzyme cyclooxygenase (Cyclooxygenase) both type 1 (Cox-1) and type 2 (Cox-2), which are an integral part of the protaglandin synthesis process. This group of drugs has anti-inflammatory properties of various tissues, relieve pain, reduce fever, prevent and relieve menstrual pain. But at the same time, the drug inhibits the mechanism of mucus covering the gastric mucosa. As a result, the gastric mucosa is irritated by gastric juice and becomes a disease of Epe (Gastric ulcer and duodenal ulcer) and gastric inflammation easily.
Before using mefenamic,
When prescribing all drugs, including mephenamic acid Here are some things to tell your doctor or pharmacist:
- History of allergy to any drug Especially mefenamic acid (Mefenamic acid), aspirin (Aspirin) and non-steroidal anti-inflammatory drugs (NSAIDs). Or tightness, difficulty breathing / difficulty breathing, etc.
- Various underlying diseases and prescription and over-the-counter medications Including dietary supplements, vitamins, and various herbal drugs that are currently or are currently being used. Because mephenamic acid may exacerbate the symptoms of your underlying condition. Or drug interactions with other drugs and / or other dietary supplements (In some cases, drugs that interact with the drug cannot be used together. But in some cases it may be necessary to use those two drugs together. Although there may be interactions between drugs that can occur In which case the doctor may adjust the dosage or increase caution when using it
-
- Taking mephenamic acid with anticoagulants (Anticoagulants) such as absinthe mab (Abciximab), acinocumarol (Acenocoumarol), Dicumarol, Heparin, Warfarin. The drugs are synergistic and can easily cause gastric bleeding [1], [ 4)
- Taking mephenamic acid along with antihypertensive drugs such as Alacepril, Alprenolol, increases the antihypertensive efficacy of the drug. These fell
- Taking mephenamic acid along with antipsychotics such as lithium may increase the side effects of psychiatric drugs [4].
- Taking mephenamic acid in combination with antidepressants such as Citalopram, estralopram. (Escitalopram), fluoxetine (Fluoxetine), Fluid Monkey was there (Fluvoxamine), taking Roxy Teen (Paroxetine), Serviced Apartments in Raleigh (Sertraline) to bleed more easily [5. )
- Taking mephenamic acid along with drinking alcoholic beverages This increases the risk of stomach and intestinal bleeding [4].
- Other drugs that may interact with these drugs include methotrexate. (Methotrexate), cyclosporine (Cyclosporine), steroids, diuretics, other NSAIDs [5].
- Having any of these symptoms or diseases, including oral disease (Dental disease), diabetes, high blood pressure, vascular disease, heart disease or circulatory disorders, have or have a history of hypertension. Who bleed more easily or are taking anticoagulants, asthma (especially asthma caused by taking aspirin), allergies, inflammatory bowel disease (ulcerative colitis), peptic ulcer disease (Gastric ulcer and duodenal ulcer), autoimmune disease or SLE (SLE), impaired liver or kidney function, or liver or kidney disease, mucosal polyps with Nasal polyps, dehydration from diarrhea or vomiting, history of stroke, history of swelling in the arms, calves, feet or ankles, have had coronary artery transplantation surgery ( Coronary bypass graft surgery) within 2 weeks before using the drug [3], [5]
- Is a person who drinks more than 3 alcoholic drinks a day or is a smoker
- If it’s a lady Should report that there is a pregnancy Or are planning a pregnancy Or are breastfeeding This is because many drugs can pass through the placenta or milk and enter the baby, potentially causing adverse effects on the baby.
Contraindications / precautions for use of mephenamic
- Do not use this medication with people with a history of allergic reaction to mefenamic acid, aspirin, or non-steroidal anti-inflammatory drugs (NSAIDs) [1].
- Do not use this drug in patients with epigastric ulcer disease, asthma, urticaria, allergic cold, various blood diseases (eg thrombocytopenia), heart disease and people who have heart vein surgery, patients with Have had a relapse from aspirin or this drug [1], [4]
- Do not use this drug in pregnant women in the third trimester (the drug may cause disability to the fetus) and the female child. (The drug may mix with milk and have adverse effects on the child) [1]
- Do not share drugs with others and do not use drugs that are worn or expired.
- This medication is contraindicated in children younger than 2 years [5] and is not recommended for use in children younger than 14 years [1].
- Avoid using mephenamic acid along with aspirin, steroids, NSAIDs, and alcoholic beverages. This may increase the risk of developing peptic ulcer disease [1].
- Caution should be exercised when using mephenamic acid in patients with cirrhosis, renal failure and heart failure [1] (patients with liver disease or kidney disease should avoid this drug. This is because the drug can cause injury and damage to both the liver and kidneys. When to use, it must be only as directed by your doctor (4] ).
How to use mephenamic
- In adults and people aged 14 years and over for the first time, the 500 mg dose (2 capsules or 1 tablet) is continued, the 250 mg dose can be repeated every 6 hours when symptoms develop. And the ability to stop taking the drug when recovering from pain (For general pain, usually should not take the drug for more than 7 days. Typically, the duration of dosing is 2-3 days) [1], [2], [5].
Instructions for use of mephenamic acid
- Take this drug with a glass of water (swallow the tablet whole Do not break, split or chew the tablet), preferably taken after meals immediately. To reduce irritation in the stomach (If the medication does not match the meal Should find snacks to eat after diarrhea)
- Generally, this medication is taken at the onset of symptoms and is given every 6 hours or up to 3 times a day (the maximum dose for adults should not exceed 500 mg) and should not be used for more than 7 days.Or use this medication strictly according to the instructions on the label or as directed by your doctor. Do not use less or more of the medication than indicated. If in doubt, ask your doctor or pharmacist [1], [4], [6].
- Mephenamic acid is considered a dangerous drug and has many side effects. Patients should not buy this drug for themselves Also, the dose for adults and children for each symptom may differ. Therefore, only advice on how to use this medication from your doctor or pharmacist [4].
- If having to undergo surgery (Including oral surgery, such as dental surgery), tell your doctor or dentist that you are using this drug. Because the drug may slow blood clotting There is an increased chance of bleeding during and after surgery.
- In case of need the drug’s effects Dynamic consecutive time should be taken to prevent any kind of Epe years [1], for example.
- Mara Dean(Ranitidine) for Dosage 300 mg 2 times a day.
- Omega omeprazole(Omeprazole) for Dosage 20 mg 2 times a day.
- Mizo Prosser Atholl(Misoprostol), the drug prostaglandin synthesis. Give each time 100-200 mcg, 4 times a day.
- Antacids(Antacids) for Dosage 30 ml per day, 7 times.
- Stop using mephenamic acid when you have the following symptoms: [5]
- Fever, redness, peeling skin, sore throat
- Nausea, vomiting, abdominal distension, low fever, loss of appetite, dark urine, pale stools, yellowing of the eyes
- Chest tightness, breathlessness, weakness, slurred speech, problems with balance Or vision
- Vomit is black or bloody Black or bloody liquid defecation
- Urinating less than usual
- Pain when urinating Or bloody urine
- Bruising, bleeding, easy bleeding, muscle pain.
How do i store mephenamic acid?
- Keep this medication in the original container it came in, tightly closed, and kept out of the reach of children and pets.
- This drug should be stored at room temperature. Keep the drug away from direct sunlight and heat. Keep the medication away from hot temperatures above 30 ° C and do not store the medication in wet or humid areas (such as in the bathroom, freezer of the refrigerator), as heat or humidity can cause deterioration of the drug.
- Discard any drug that is worn out or has expired.
When you forget to take mephenamic
If you forget to take mephenamic acid To take the medicine as soon as possible But if it is close to the next meal You can skip taking the next pill straight away. Without increasing the dose twice or more than usual And the ability to stop taking the drug when recovering from pain
Mephenamic side effects
- The main side effect of mephenamic acid is that it may cause peptic ulcer and gastritis, especially in the elderly. Which may cause bleeding (Vomiting blood or black stools) or perforation of the stomach [1]
- May cause headache, dizziness, dizziness, blurred vision, ringing in the ears, nausea, vomiting, drowsiness, weakness, sweating, runny nose, dry mouth, tightness, gastric colic, chest colic. Abdominal discomfort, stomach pain, abdominal pain, constipation or diarrhea. Hepatitis or liver enzymes (AST, ALT) elevated, recurrent allergy. Low white blood cells Low blood platelets Anemia from bone marrow atrophy [1], [3], [5]
- May cause fluid retention, causing hands and feet to swell. High blood pressure And it can make people with a heart attack relapse [1].
- May cause allergic reactions to drugs such as hives, itchy rashes, asthma, Stevens-Johnson syndrome. (Stevens-Johnson syndrome) anaphylactic shock. (Anaphylactic shock) [1]
- Anaphylactoid shock may occur. (Anaphylactoid) in people using this drug for the first time [1].
- If using high-dose mephenamic acid The drug may inhibit the coagulation of platelets. Bleed The use of this drug should therefore be cautioned in patients with bleeding disorders (blood disorder) and patients on anticoagulants [1].
- If using mephenamic acid for a long time It may cause chronic renal failure [1]. Another information indicates that continued exposure may cause thrombocytopenia. (Makes bleeding easy and difficult to stop) anemia / anemia Irritation in the abdomen Constipation or diarrhea Ulcers in the stomach and intestines, headache, nervousness, drowsiness, asthma, heart failure. High blood pressure, palpitations, swollen skin, hives, liver and kidney malfunctions [4].
- Using NSAIDs, including mefenamic acid, increases the risk of ischemic heart disease. And cerebrovascular disease This risk increases with prolonged use of the drug. They also have risk factors for cardiovascular disease [5].
- Side effects that require immediate medical attention to the doctor or pharmacist include fatigue, fatigue, and fatigue. Vomit blood or has a color like ground coffee beans Black stools Urine contains blood Weight gain for unknown reasons or swelling, hives, rash, itching, blurred vision, blurred vision, loss of appetite, jaundice, yellowing of the eyes. Symptoms like colds, blisters, fever, swelling of the throat, tongue, lips, eyes, hands, feet, ankles or calves, difficulty swallowing or breathing. Abnormal rapid heartbeat, pale skin, back pain, difficulty urinating, burning in urination, abdominal pain or cramping [3].
