Fondaparinux: Function, Rules of Use, Dosage, Side Effects

Fondaparinux is a medicine to prevent and treat deep vein thrombosis (DVT) or blood clots in deep veins (veins). Find out what medicines fondaparinux, function, rules of use, dosage, side effects, etc.

Summary of Fondaparinux Drug Information

The following is general information on fondaparinux medicine:

Medicine name Fondaparinux
Drug Content Fondaparinux
Drug class Anticoagulants, Antiplatelet and Fibrinolytic (Thrombolytic)
Category Prescription drugs
Benefits of Medication Blood thinning medication to treat blood clots in veins
Contraindicated Active large bleeding, bacterial endocarditis, and a history of heparin-induced thrombocytopenia
Drug preparations Injection fluid
Drug Prices Rp.810,000 Fondaparinux Sodium – 2.5 mg / 0.5 ml (1 box for 2 injections)

The price of fondaparinux medicine may differ in each pharmacy. Consult with your pharmacist the price of this drug in other sizes.

What is Fondaparinux medicine?

Fondaparinux is a drug to prevent blood clots that occur in deep vein thrombosis (DVT). Deep vein thrombosis (DVT) is a serious condition when veins or veins develop blood clots.

This blood clotting can occur in the lower legs, thighs, or other body parts. This condition can also cause blood clots in the lungs (pulmonary embolism) . One way to overcome DVT is by consuming fondaparinux anticoagulant drugs.

The way the fondaparinux drug works is by blocking the activity of substances that clot blood. This drug is usually also used as a combination drug with warfarin (a blood thinning drug).

Fondaparinux Trademark

This drug is sold as a generic drug Fondaparinux. Other trademarks similar to this drug are:

  • Arixtra
  • Arixtra 5 mg / dose
  • Arixtra 7.5 mg / dose
  • Arixtra 10 mg / dose
  • Diviti

Fondaparinux is a prescription drug that cannot be bought haphazardly. It is better to ask the medical services how to get this drug.

Function of Fondaparinux medicine

Fondaparinux is a prescription drug that can only be used based on doctor’s instructions to treat blood clots from deep vein thrombosis (DVT).

Based on the Centers for Disease Control and Prevention (CDC), symptoms of deep vein thrombosis (DVT) include:

  • Swelling at the ankles, feet, or one side of the foot
  • Pain and cramps in the calf
  • Leg area of ​​the skin feels warmer
  • Swelling or blood clots in the arm

This blood clots may not be realized in sufferers, until chronic clots occur. In more severe conditions, DVT triggers blood clots in the lungs, also called pulmonary embolism.

Fondaparinux is used to thin the clotted blood before blood clots in the lungs. Additionally, this drug may be used for other indications not listed in this information. Talk to your doctor again about the function and use of this drug.

Also Read:  7 Signs of Blood Clots Happening in the Body, Beware!

Fondaparinux Medication Warning

Before using this medicine, please pay attention to some important warnings, including:

  • Follow all instructions for use according to doctor’s instructions or drug label instructions.
  • Tell your doctor if you have a history of granisetron-related allergies beforehand.
  • Tell your doctor if you have a history of any drug allergy.
  • Tell the doctor all of your medical history and a list of medications that may be currently in use.
  • Do not use this blood thinning medication if you are under 50 kilograms.
  • This drug can cause long-term paralysis in the spinal cord if you use it while receiving spinal (epidural) anesthesia.

Also, please be careful when using this medicine if you have a history of medical conditions such as:

  • Active or uncontrolled bleeding.
  • Severe kidney disease.
  • Infection of your heart lining (bacterial endocarditis).
  • Low platelet level.
  • Spinal abnormalities due to genetic factors.
  • Spinal catheter.
  • History of spinal surgery.
  • Just underwent epidural anesthesia.
  • Using nonsteroidal anti-inflammatory drugs (NSAIDs).
  • History of blood disorders.
  • Stroke history.
  • History of eye disorders due to diabetes.
  • High blood pressure
  • History of stomach or intestinal bleeding.
  • Brain, spinal, or eye surgery.
  • History of latex allergy.
  • History of liver or kidney disease.
  • Pregnant, nursing, or planning a pregnancy.

Use the medication according to the instructions for use to prevent the risk of side effects and maximize the function of the drug to cure the symptoms you are experiencing.

Fondaparinux Drug Interaction

Drug interactions are drug reactions when meeting other drugs when you use two or more drugs, including vitamins or herbal medicines. These reactions can weaken or enhance the way one or both of the drugs you use work.

Possible interactions of fondaparinux when used with other drugs, including increasing the risk of bleeding if taken together with Desirudin drugs, fibrinolytic drugs, glycoprotein IIb / IIIa receptor antagonists, heparin, heparinoids, or LMWH.

In addition, this drug may have interactions when used in conjunction with the drug:

  • Aspirin
  • Atrovent
  • Celebrex
  • Clexane
  • Colace
  • Combivent
  • Crestor
  • Dabigatran
  • Enoxaparin
  • Iron sulfate
  • Lasix
  • Lipitor
  • MiraLAX
  • Morphine Sulfate ER
  • Paracetamol
  • Percocet
  • Protonix
  • Reglan
  • Rivaroxaban
  • Ticagrelor
  • Tylenol
  • Vitamin B12
  • Vitamin C
  • Vitamin D3
  • Zofran

It is recommended not to take two types of drugs at the same time except according to the doctor’s prescription. Notify the doctor if you are using other drugs so that drug interactions do not occur.

Also Read:  3 Factors That Cause Blood to Clot on Menstruation

Fondaparinux Side Effects

Here are some of the possible side effects:

  • Nausea
  • Throw up
  • Fever
  • Rash
  • Insomnia
  • Dizzy
  • Cough
  • Confusion
  • Diarrhea

Other severe side effects that may occur, including:

  • Hip fracture
  • Anemia
  • Hypotension
  • Postoperative bleeding
  • Reaction on the part of the body that is operated on
  • Epidural hematoma
  • Permanent paralysis

This information does not contain all the risks of side effects of fondaparinux drugs. Other side effects may occur. Stop using the drug immediately and contact a doctor if severe side effects occur.

Fondaparinux Drug Dosage

The following information about dosages of fondaparinux drug:

  • Superficial venous thrombosis : Use an injection dose of 2.5 mg once daily for 30-45 days.
  • Preventing Postoperative Venous Thrombosis Clots: 2.5 mg once daily starting 6-8 hours after surgery and continued for about 5-9 days to 32 days according to the patient’s condition.

Doses for blood clots that begin in the vein ( Venous Thromboembolism ) are based on the patient’s body weight, namely:

  • <50 kg: 5 mg once a day
  • 50-100 kg: 7.5 mg once a day
  • > 100 kg: 10 mg once a day

The duration of treatment is 5-9 days or until it is allowed to take oral anticoagulation drugs. This information does not replace a doctor’s prescription. Please use the dosage according to doctor’s instructions.

Also Read:  Blood: Function, Components, Disease

How to use Fondaparinux

Here’s how to use fondaparinux:

  • Fondaparinux is used to inject fluid into the skin.
  • Use the sterile injection provided.
  • The injection is done by a doctor, then the doctor will probably teach you the correct injection.
  • This drug should not be injected directly into muscles or veins.
  • This medicine might make you bleed easily.

If you still have questions regarding the use of this drug, please contact your doctor, pharmacist, or health care provider.

Fondaparinux Storage Instructions

Storing drugs in the right place will affect the performance of the drug. The following is a guide to storing medicines properly so they are not damaged:

  • Exposure to light, heat, water and humidity can damage the drug content.
  • Store your medicines in a cool, dry place or under 30 ° C.
  • Use the needle and syringe only once and then put it in an anti-puncture “sharp” container.
  • You can store medicines in a special medicine box, first aid kit, or cabinet drawer.
  • Stay away from drugs from the stove, sink, and all heat equipment.
  • Always keep medicine in its original container.
  • Do not dispose of drugs carelessly because it will pollute the environment.
  • Always keep your medication out of reach and out of reach of children.
  • Ask your pharmacist for specific storage instructions.

That’s the complete discussion about the rules for using fondaparinux drugs to treat blood clots in veins. This health information does not replace a doctor’s prescription. Please only use this medicine according to doctor’s rules for more effective treatment and healing. I hope this information is helpful


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