The Tacrolimus is used after a liver transplant, the kidney or the heart to prevent organ rejection . It is often used in combination with other drugs, and sometimes also used in the treatment of Crohn’s disease .

What is Tacrolimus?

Tacrolimus works by decreasing the activity of the immune system , as it is an immunosuppressant drug.

How is Tacrolimus taken?

The administration of Tacrolimus takes place orally , generally in the form of capsules to be taken twice a day, allowing 12 hours to pass between one intake and another. The doctor may, if necessary, modify the initial dose of the prescription.

Side effects of Tacrolimus

Tacrolimus can increase the risk of contracting infections, even serious ones. It can also increase the risk of skin cancer, an increase in blood pressure , or the risk of diabetes .

Its other possible side effects include:

  • headache
  • uncontrollable tremors
  • diarrhea
  • constipation
  • nausea
  • He retched
  • heartburn
  • loss of appetite
  • insomnia
  • dizziness
  • weakness
  • back or joint pain
  • burning, numbness, pain or tingling in the hands or feet

A doctor should be contacted as soon as possible in case of:

  • swelling of the mouth, face, lips or tongue, hands, arms, feet, ankles or calves
  • weight gain
  • bleeding or bruising
  • convulsions
  • reduced urination, painful or associated with burning
  • coma
  • rash
  • urticaria
  • itch
  • breathing difficulties
  • feeling of tightness or chest pain

Contraindications and warnings on the use of Tracolimus

Before starting a treatment with Tacrolimus it is essential to inform your doctor:

  • of any allergies to the active substance, its excipients, to any other drug , to foods or other substances;
  • of the medicines, phytotherapics and supplements taken, in particular Amphotericin B, antacids, antibiotics, antifungals, Bromocriptine, calcium channel blockers, Caspofungin, Chloramphenicol, Cimetidine, Cisapride, Cisplatin, Danazol, diuretics, Ganciclovir, hormonal contraceptive hormones HIV, Lansoprazole, seizure medications, Methylprednisolone, Metoclopramide, Nefazodone, Omeprazole, Rifabutin, Rifampicin, Hypericum and Sirolimus;
  • if you have recently stopped taking Cyclosporine ;
  • if you suffer (or have suffered) from heart, kidney or liver disease ;
  • if you are pregnant or breastfeeding ;
  • before undergoing a vaccination .

The intake of grapefruit or grapefruit juice should be avoided during treatment with Tacrolimus.Your doctor, surgeon and dentist should always be informed of taking Tacrolimus.