What is Indomethacin?

Indomethacin is an anti-inflammatory non-steroidal (NSAIDs). It works by blocking the production of substances responsible for the appearance of pain, fever and inflammation.

What is Indomethacin for?

Indomethacin is used to reduce moderate or intense pain and to treat the sensitivity, swelling and stiffness caused by osteoarthritis , rheumatoid arthritis and ankylosing spondylitis.It can also be used to treat shoulder pain caused by bursitis and tendinitis and in case of acute gouty arthritis .

It is also sometimes used to treat fever, pain and inflammation associated with various ailments or trauma, to decrease the level of calcium in the blood or to treat a certain type of hypotension (very low blood pressure in the arteries).

How is Indomethacin taken?

Indomethacin can be taken orally in the form of capsules, prolonged-release tablets or to be dissolved. Usually it is taken 2-4 times a day ; in the case of prolonged-release medicines, it can be reduced to 1-2 intakes a day . It should be taken with food or immediately after a meal. Eventually, you can take the drug with an antacid .

Instead, it can be taken 2-4 times a day in the form of rectal suppositories .

Side effects of Indomethacin

Possible side effects of Indomethacin include:

  • headache
  • dizziness
  • He retched
  • diarrhea
  • constipation
  • rectal irritation
  • constant feeling of having to clear the intestines
  • annoying hearing disorders

It is good to contact a doctor immediately in case of:

  • unjustified weight loss
  • temperature
  • blisters
  • rash
  • itch
  • urticaria
  • swelling of the eyes, face, tongue, lips, throat, hands, feet, ankles or calves
  • difficulty breathing
  • difficulty swallowing
  • hoarseness
  • pallor
  • fast heart beat
  • excessive tiredness
  • bruising or bleeding
  • lack of energy
  • nausea
  • loss of appetite
  • pain in the upper right side of the abdomen
  • flu-like symptoms
  • yellowish coloration of the skin
  • cloudy , colorless urine
  • urine with blood
  • backache
  • difficulty or pain in urination
  • vision problems (e.g. fogging)

Contraindications and warnings on the use of Indomethacin

Taking NSAIDs such as Idomethacin may increase your risk of heart attack and stroke . Additionally, these medications can cause stomach or intestine ulcers, bleeding, or perforation.

The drug may interfere with the ability to drive and operate dangerous machinery. Its side effects can worsen with alcohol intake.

Before you start taking Indomethacin you should tell your doctor:

  • of allergies to the active substance, to aspirin or other NSAIDs, their excipients or to any other drug;
  • of medicines, phytotherapy and supplements taken, citing in particular ACE inhibitors, angiotensin II receptor antagonists, beta blockers, Cyclosporine, Digoxin, diuretics, Lithium, Methotrexate, Phenytoin and Probenecid;
  • if you suffer (or have suffered) from asthma (especially in case of frequent blocked nose or nasal polyps), convulsions, Parkinson’s, depression or other psychological disorders, liver or kidney pathologies, proctitis or blood loss from the rectum;
  • if you are pregnant or breastfeeding.

Surgeons and dentists should also be informed of any ongoing Indomethacin treatment.

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