What is Colchicine?

The Colchicine is used mainly to treat and prevent gout attacks (recurrent attacks of acute inflammatory arthritis with pain, redness and swelling of the joints).

It is also used in the treatment of family Mediterranean fever.

What is Colchicine?

The exact functioning mechanism of Colchicine is unknown. It acts on certain proteins within the body which can alleviate the symptoms of gout.

How is Colchicine taken?

Colchicine is generally taken orally in the form of tablets or capsules. However, it can also be administered through injections directly into the vein.

Colchicine side effects

Colchicine can make you more sensitive to infections: it is important to avoid contact with people with infectious diseases and to inform the doctor in case of fever, sore throat, rash or chills.

In addition, the drug can lower platelets, exposing you to an increased risk of bruising and bleeding. For this reason it is good to contact a doctor even in case of dark stools or with blood inside them.

Other possible side effects of colchicine include:

  • diarrhea
  • nausea
  • stomach ache
  • He retched

It is good to contact a doctor immediately in case of:

  • rash
  • urticaria
  • itch
  • breathing difficulties
  • feeling of tightness in the chest
  • swelling of the mouth, face, lips or tongue
  • muscle pain, tenderness or weakness (with or without fever or fatigue)
  • numbness or tingling in the fingers or toes
  • pale, gray lips, tongue or palms
  • unusual tiredness or weakness


Colchicine should not be taken if you are suffering from liver or kidney disorders and are taking atazanavir, boceprevir, clarithromycin, cyclosporine, darunavir, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posazonazole, tanolazin or ritonavir, saquinavir, telaprevir, telithromycin, tipranavir or troleandomycin.

During the treatment you should not eat grapefruit or drink its juice.

Also, before starting to take colchicine it is important to tell your doctor:

  • of any allergies to the active substance, to its excipients or to any other drug or food
  • of the other medicines, phytotherapics and supplements that you are taking, in particular digoxin, fibrates, statins, amprenavir, aprepitant, atazanavir, azole antifungals, boceprevir, cyclosporine, darunavir, diltiazem, fosamprenavir, fosaprepitant, indinavir, antibiotics macr nelfinavir, ranolazine, ritonavir, sympathomimetic drugs and any medicinal product containing ritonavir, saquinavir, telaprevir, telithromycin, tipranavir or verapamilse you suffer (or have suffered) from liver or kidney problems
  • if you are pregnant or breastfeeding

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