The clonidine is an antihypertensive drug that acts on the α2-adrenergic receptors in the central nervous system. It acts at the level of the central nervous system, minimizing the activation of the sympathetic system, heart rhythm and blood pressure, thanks to its selective activation capabilities of the presynaptic alpha-2 receptors of the central nervous system.
What is clonidine used for?
It is generally prescribed in association with diuretics in the treatment of hypertension .
How is Clonidine taken?
It usually occurs orally (it is easily absorbed from the gastro-enteric tract).
Side effects of Clonidine
The most common side effects associated with taking Clonidine are:
- general malaise;
- dermatological disorders: skin rush , urticaria , pruritus , alopecia ;
- gastrointestinal disorders: feeling of nausea , retching, loss of appetite, constipation, dry mouth;
- nervous system disorders: tiredness, confusion, perceptual disturbances, hallucinations, depressive symptoms.
Contraindications and warnings associated with the use of Clonidine
Given the absence of data relating to its effect on the fetus and newborn during breastfeeding, it would be advisable to avoid taking it in these two phases of the woman’s life.
Since the hypotensive action of Clonidine can be increased by the simultaneous administration of other antihypertensive drugs, it is necessary to pay due attention to the simultaneous intake of diuretics, calcium antagonists, ACE inhibitors. On the contrary, the therapeutic action of this drug could be inhibited by the use – in the same time interval – of Fans (non-steroidal anti-inflammatory drugs), antidepressants or other drugs that increase the hydro-saline retention.