How does Clomipramine work?

The clomipramine is used for treating obsessive-compulsive disorder .

How does Clomipramine work?

It is a tricyclic antidepressant that works by increasing the brain activity of molecules that help fight obsessive-compulsive behaviors.

How is Clomipramine taken?

It is administered orally, usually in the form of capsules. It is advisable to take it on a full stomach to avoid gastric problems.

Side effects of Clomipramine.

Its possible side effects include:

  • loss or loss of appetite
  • feeling sick
  • nightmares
  • sweats
  • feeling of tiredness
  • stomach discomfort
  • retching
  • generic weakness
  • changes in body weight
  • constipation
  • discharge of diarrhea
  • dizziness
  • drowsiness
  • dry mouth
  • headache
  • irritability

It is important to seek medical attention immediately in case of:

  • rash , hives or itching
  • difficulty breathing
  • problems with the sexual sphere
  • chest pain
  • confused state
  • fainting
  • fast, slow or irregular heartbeat
  • feverish state
  • redness
  • feeling of heaviness or tightness in the chest
  • swelling of the mouth, face, lips or tongue
  • frequent or difficult urination
  • behavioral changes
  • mood swings
  • numbness or tingling
  • panic attacks
  • tinnitus
  • seizure symptoms
  • severe dizziness
  • severe sleepiness
  • sore throat
  • stomach ache
  • suicidal instincts
  • swollen testicles
  • tremors
  • insomnia
  • difficulty walking or maintaining balance
  • tics (face or tongue)
  • stiffness or uncontrolled movements at the joint level
  • bruising or bleeding
  • worsening of depressive syndrome
  • jaundice


The drug should not be taken if linezolid or MAO inhibitors have been taken in the previous 14 days or if you have had a heart attack.

Furthermore, before starting the treatment it is important to make the doctor aware:

  • about the presence of any allergies to the active substance , to its excipients or to any other drug or food
  • of other medicines, phytotherapy and supplements already taken or being taken (in particular busipyrone, carbamazepine, digoxin, sympathomimetics, clonidine, guanethidine, guanfacine, cimetidine, fentanyl, flecainide, haloperidol, lithium, methylphenidine, phenothiazine, propenone , SSRIs, SNRIs, St. John’s wort, tramadol, triptans, tryptophan, linezolids, MAO inhibitors, barbiturates, anticholinergics, anticoagulants, thyroid drugs and medicines containing methylene blue)
  • in case of previous heart attack
  • in case of alcohol abuse problems
  • if you suffer (or have suffered in the past) from hyperthyroidism , adrenal problems, suicidal thoughts, bipolar or other psychiatric diseases, glaucoma, increased intraocular pressure, heart, kidney or liver disease, diabetes, convulsions, difficulties urination, porphyria or other blood diseases
  • in the case of pregnant women or breastfeeding women

It is also advisable to always inform doctors, surgeons and dentists about ongoing clomipramine treatment.

The drug may take a few weeks before it becomes effective, but treatment should never be stopped without medical advice. It can also interfere with the driving or maneuvering abilities of dangerous machinery; sleepiness associated with its use can be aggravated by alcohol intake or other medications.

The clomipramine can generate dangerous dizziness; for this reason, during treatment, it is important to be careful when standing from a lying or sitting position, especially in the morning. Furthermore, s recommends not to overheat: it increases the risk of serious cardiac events.

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