What is Chlorpromazine?

The Chlorpromazine is used to treat certain psychiatric disorders (eg schizophrenia), the manic phase of bipolar disorder, anxiety and restlessness before surgery, porphyria (alteration of enzyme activity), several behavioral disturbances in children, nausea , vomiting and severe hiccups.In combination with other drugs, it is also used in the treatment of tetanus symptoms.

What is Chlorpromazine?

Chlorpromazine is a phenothiazine : it belongs to a group of organic compounds having both antipsychotic and antihistamine properties. Its exact mechanism of operation is unknown.

How is Chlorpromazine taken?

Chlorpromazine can be administered orally (usually in the form of concentrates, capsules, syrups or tablets), rectally or through an injection.

Chlorpromazine side effects:

Chlorpromazine can increase the sensitivity of the skin to the sun. In addition, it can trigger uncontrolled muscle movements, increase prolactin and blood sugar levels, increase the risk of neuroleptic malignant syndrome.

Other possible side effects include:

  • agitation
  • constipation
  • dizziness
  • drowsiness
  • dry mouth
  • dilated pupils
  • nervousness
  • nausea
  • stuffy nose

It is good to contact a doctor immediately in case of:

  • rashes
  • urticaria
  • itch
  • breathing difficulties
  • chest pain or tightness
  • swelling of the mouth, face, lips or tongue
  • confusion
  • reduction of coordination
  • drool from the mouth
  • fainting
  • rapid, slowed or irregular heart beat
  • face that looks like a mask
  • muscle spasms in the face, neck or back
  • muscle weakness
  • new psychiatric problems or aggravation of pre-existing ones
  • numbness of arms or legs
  • prolonged or painful erection
  • restlessness
  • convulsions
  • severe or persistent constipation, dizziness, headache or drowsiness
  • stiff muscles
  • sudden shortness of breath or vomiting
  • swelling of the hands, ankles or feet
  • symptoms of an infection
  • symptoms of a liver problem
  • tremors
  • difficulty urinating
  • uncontrolled tics and twists
  • bleeding and bruising
  • strange eye movements or inability to move them
  • excessive sweating
  • unusual tiredness or weakness
  • pallor
  • vision problems
  • and if you walk by dragging your feet.


Chlorpromazine can impair your ability to drive and operate dangerous machinery, especially when taken together with alcohol or other medicines. It can also cause dangerous dizziness when getting up from a lying or sitting position, especially in the morning, in the heat, if you have a fever, if you are exercising or if you are drinking alcohol.

Chlorpromazine should not be taken if you have recently consumed large quantities of alcohol or medications that can cause drowsiness, such as barbiturates or narcotics. Furthermore, it should not be taken together with amiodarone, bretilio, astemizolo, cabergoline, cisapride, dofetilide, metoclopramide, pergolise, quinidine, sotalol, tefrenadine or tramadol. It is also important to inform your doctor before taking:

  • allergies to the active substance, its excipients or other drugs (especially other phenothiazines and sulphites) or foods;
  • of medicines, officinal medicines and supplements taken, citing in particular drugs that increase the risk of prolongation of the QT interval, medicines against allergies or against coagulation problems, tumors, infections, inflammations, pains, heart problems, pressure or cholesterol highs, irregular heartbeats, mood disorders or psychiatric problems, nausea or vomiting, Parkinson’s, convulsions, gastrointestinal disorders or overactive and multivitamin bladder, herbal tea, coenzyme Q10, garlic, ginseng, gingko and St. John’s wort;
  • if you suffer (or have suffered) from heart, liver, blood or kidney problems, high blood pressure, diabetes, bone marrow problems, neuroleptic malignant syndrome, tardive dyskinesia, prostate hypertrophy, convulsions, urination difficulties, psychiatric disorders or mood, pheochromocytoma, asthma, lung infections or breathing problems, increased pressure in the eye, glaucoma (or if you are at risk of glaucoma), Alzheimer’s or other forms of dementia, Parkinson’s, Reye’s syndrome, elevated prolactin levels or tumors;
  • in case of recent or scheduled myelogram;
  • if you are pregnant or breastfeeding;
  • During treatment you should not take alcohol.

It is good to inform doctors, surgeons and dentists about taking Chlorpromazine.

by Abdullah Sam
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