How does Chloramphenicol work?

The Chloramphenicol is used in the treatment of certain serious infections caused by bacteria. Typically, it is used in cases where other antibiotics cannot be used .

How does Chloramphenicol work?

The Chloramphenicol exerts a bacteriostatic action: it blocks the creation of proteins by bacteria without killing themselves.

How is Chloramphenicol taken?

Chloramphenicol is administered intravenously. The treatment is carried out in the hospital; in general, it requires administration every six hours and its duration varies from case to case.

As the patient’s condition improves, the doctor may decide to complete the therapy using another antibiotic.

Chloramphenicol side effects:

In premature babies, infants and children of women who received chloramphenicol during childbirth, the drug can cause the so-called ” gray baby syndrome “. Its possible symptoms, which typically appear after 3-4 days of treatment, include stomach swelling, vomiting, cyanosis (bluish coloring of the skin due to oxygen deficiency in the blood), low blood pressure and breathing difficulties. In the worst case, this condition can be fatal.

Other possible side effects of chloramphenicol include:

  • nausea
  • He retched
  • diarrhea
  • sores on the tongue or oral cavity
  • headache
  • depression
  • confusional state

It is important to contact a doctor immediately if bleomycin therapy triggers:

  • urticaria
  • rashes
  • itch
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or calves
  • hoarseness
  • difficulty swallowing or breathing
  • loose or bloody stools
  • stomach cramps
  • muscle pain or weakness
  • sweats
  • numbness, pain or tingling in arms or legs
  • sudden vision problems
  • pain in moving the eyes


Before treatment with chloramphenicol it is important to inform your doctor:

  • any allergies to the active substance or its excipients
  • of any previous treatments with chloramphenicol
  • of medicines, phytotherapy and supplements taken, in particular anticoagulants, aztreonam, cephalosporins, vitamin B12, folic acid, iron supplements, oral antidiabetic agents, phenobarbital, phenytoin, rifampicin and medicines that can reduce the number of blood cells
  • if you suffer (or have suffered) from kidney or liver disease
  • if you are pregnant or breastfeeding

It is important to inform surgeons or dentists of any chloramphenicol therapies.

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