Apomorphine is used in the treatment of loss of ability to control movements linked to advanced Parkinson’s .
What is Apomorphine?
Apomorphine works by stimulating the dopamine neurotransmitter receptors , thus facilitating the improvement of motor functions.
How do you take Apomorphine?
Apomorphine is taken through subcutaneous injections .
Side effects of Apomorphine
Apomorphine can cause drowsiness and sudden sleep. It can also cause compulsive behaviors and, in a few situations, prolonged and painful erections or chest pains, heart attacks and sudden death.
Among its other possible side effects we also find:
- dizziness ;
- nausea ;
- pallor ;
- a runny nose;
- He retched;
- burning, itching, pain, swelling or redness at the injection site.
It is essential to notify the doctor immediately in the presence of:
- skin rash ;
- urticaria ;
- itching ;
- breathing problems;
- feeling of tightness or chest pain;
- swelling of the mouth, face, lips or tongue;
- strange thoughts;
- behavioral changes;
- bad jaw or left arm;
- movement difficulties;
- fainting ;
- fast or irregular heart beat
- increased sweating ;
- changes in mood or behavior;
- compulsive behavior;
- weakness on one side of the body;
- painful or prolonged erections;
- dizziness, drowsiness, nausea or severe or continuous vomiting;
- shortness of breath;
- sudden and uncontrollable movements;
- swollen arms, hands, legs or feet;
- changes in the appearance of a mole or other skin formations;
- impaired vision or speech.
Contraindications and warnings on the use of Apomorphine
Apomorphine may not be indicated in the presence of convulsion, impaired state of consciousness, low blood pressure and if antiemetics are being taken.
Before taking it is essential to warn the doctor :
- the possible allergy to the active substance, its excipients, every other medicine, food or other substances (specifically to sulfites);
- of the use of other drugs, phytotherapics and supplements , specifically anti-emetics, antiarrhythmics, Arsenic, azole antifungals, Bepridyl, Cisapride, Droperidol, H1 antagonists, Ketolides, Macrolides, Phenothiazines, type 5 Phosphodiesterase inhibitors, Pimozides, Tricyclic antidepressants, Ziprasidone, medicines for high blood pressure, nitrate or other vasodilators, butyrophenones, metoclopramide, Thioxanthens and any medicine that could increase the danger of prolonging the QT interval;
- if you suffer (or have suffered) from low blood pressure, dizziness , fainting, heart problems, abnormal heart rhythm, low potassium or magnesium in the blood, asthma, liver or kidney disorders, mood or behavior disorders, insomnia, disorders to the blood vessels or brain;
- in the presence of stroke ;
- if you consume alcohol regularly;
- case of a history of alcohol or drug abuse;
- if you are pregnant or breastfeeding .
L ‘ Apomorphine may impair ability to drive or operate dangerous machinery; these effects can worsen with alcohol and certain medications, for example sleeping pills or muscle relaxants. In addition, alcohol, heat, physical activity and fever can increase dizziness caused by the medicine; to prevent them, it is good to get up slowly, mainly in the morning, and sit or lie down at the first signs of dizziness.
Therapy should never be stopped suddenly without the doctor’s permission.