t fights bacteria by inhibiting the synthesis of their cell wall. In particular, Amoxicillin inhibits the major component of the cell wall of both Gram positive and Gram negative bacteria , that is, the cross link between the linear polymers of peptidoglycan .
What is Amoxicillin used for?
It is a bactericidal antibiotic with a broad spectrum of action that is used in particular in the treatment of:
- respiratory tract infections (bronchopneumonia, pneumonia, bronchiectasis, pharyngitis , tonsillitis , sinusitis, otitis media, acute and chronic bronchitis, lung abscess);
- in spleen infections;
- in septicemias, peritonitis and endocarditis;
- in postoperative sepsis;
- in the treatment of acute otitis media;
- in ENT and stomatological infections;
- in urogenital tract infections;
- in skin and soft tissue infections;
- in gastrointestinal infections, including biliary infections, salmonellosis.
In several cases, amoxicillin is the drug that is primarily chosen over other antibiotics beta-lactams, because better absorbed after oral administration.
How is Amoxicillin taken?
It can be administered as a suspension, drops, tablets or capsules for oral use or as a solution for injections (to be practiced intravenously or intramuscularly).
Side effects of Amoxicillin
The undesirable effects attributable to the use of Amoxicillin are manifold, the severity of which may depend on the duration of the treatment – which can extend from five days to two weeks – and on the individual sensitivity to the active substance:
- gastrointestinal complaints: nausea , abdominal pain, vomiting, diarrhea , gastritis;
- hematological disorders: impaired platelet function, increased bleeding time, anemia , purpura, neutropenia, leukopenia , thrombocytopenia, pancytopenia, reversible agranulocytosis, petechiae ;
- liver disorders: increased transaminases , jaundice , cholestatic hepatitis;
- cardiovascular disorders: vasculitis;
- central ailments: migraine , dizziness ; insomnia;
- dermatological disorders: skin rash , erythema multiforme, toxic epidermal necrolysis and exfoliative dermatitis, bullous rash, maculopapular rash;
- urogenital disorders.
Contraindications and warnings on the use of Amoxicillin
Its use is contraindicated in the case of:
- patients with infections supported by betalactamase-producing pathogens;
- patients with known risk for allergy;
- hypersensitivity to penicillins and cephalosporins;
- patients with mononucleosis, viral infections, lymphatic leukemia .