Properties of Triazole

Triazoles also have several useful properties related to the regulation of plant growth. They have an effect on the chlorophyll content in your tissues, extend the assimilation period and improve photosynthesis, thus extending the period of grain filling.

It is a surprisingly stable structure compared to other organic compounds with three adjacent nitrogen atoms. However, vacuum flash pyrolysis at 500 ° C leads to the loss of molecular nitrogen (N 2 ) to produce aziridine . Certain triazoles are relatively easy to cleave due to so – called chain-ring tautomerism . A demonstration is found in the Dimroth Transposition .

According to these characteristics we could say that the Triazoles are apparently the same and that we could use them interchangeably for any disease, however, this is not the case. When analyzing some chemical characteristics (their genesis, origin), we find differences in their sizes (molecular weights), solubilities, and partition coefficients, which make or mark differences in their modes of action, giving each molecule special characteristics.

The 1,2,3-triazole is one of the two chemical compounds with molecular formula C isomer 2 H 3 N 3 called triazoles , having a five – membered ring of two carbon atoms and three nitrogen atoms. 1,2,3-Triazole is an aromatic heterocycle . [two]

The substituted 1,2,3-triazoles can be produced using an azide and an alkyne by the Huisgen reaction in which a 1,3-dipolar cycloaddition reaction occurs .

1,2,3-Triazole is used in research as a building block of more complex chemical compounds, such as tazobactam drugs.


The substituted 1,2,3-triazole can be prepared using the Huisgen azide-alkyne Cycloaddition , which is a 1,3-dipolar cycloaddition between an alkyne and an azide . It is outlined in the following figure:


The reaction is not regioselective : the alkyne fraction R2 may be attached to the carbon atom at position 4 or 5, as shown in the following reaction:


There is also a variant that makes use of a copper (I) catalyst, for example copper (I) chloride or copper (I) iodide, which allows the reaction to be brought to room temperature. That reaction is regioselective: it simply gives the 1,4-disubstituted triazoles.


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