How does Pioglitazone work?

The Pioglitazone is a drug that is used in the treatment of type 2 diabetes . Usually it is combined with the intake of other drugs, and its action is assisted by appropriate nutrition and adequate physical activity.

How does Pioglitazone work?

The action of Pioglitazone involves an increase in insulin sensitivity , or the hormone responsible for controlling the level of sugar in the blood.

How is Pioglitazone taken?

Pioglitazone is administered orally in the form of tablets. As a rule, its dosage requires the administration of one dose per day. It is possible that the doctor prescribes a low dose, which is then gradually increased if necessary.

Side effects of Pioglitazone

Pioglitazone can cause congestive heart failure or aggravate it.

Other potential side effects of the drug include:

  • headache
  • muscle pain
  • pain in arms or legs
  • sore throat
  • gas

The doctor should be contacted immediately if one of the following symptoms occurs:

  • vision problems
  • urination problems
  • cloudy or colorless urine
  • blood in the urine
  • back or abdomen pain

Pioglitazone can also cause liver problems. Your intake should therefore be stopped, and the doctor should be contacted immediately in case of:

  • nausea
  • He retched
  • loss of appetite
  • pain in the upper right side of the abdomen
  • flu-like symptoms
  • dark urine
  • jaundice
  • bleeding or bruising
  • lack of energy

Taking Pioglitazone may, according to some clinical studies, be associated with a fracture in the hands, arms and feet in the case of women, or even with an increased risk of bladder cancer .

Contraindications and warnings on the use of Pioglitazone

Pioglitazone should not be used in the treatment of type 1 diabetes , nor in that of diabetic ketoacidosis . In fact, this substance takes about two weeks before it can reduce the blood sugar level in the case of type 2 diabetes . To fully enjoy its benefits, it can take up to three months to hire. In any case it is important not to stop the therapy without the doctor to indicate it.

Pioglitazone can increase the chances of conception even in the presence of an irregular menstrual cycle.

Before starting Pioglitazone treatment, you should inform your doctor:

  • of allergies to the active substance or other drugs;
  • of the other medicines, phytotherapy and supplements taken, remembering to mention in particular other antidiabetics, Insulin, Atorvastatin, Gemfibrozil, hormonal contraceptives, Ketoconazole, Midazolam, Nifedipina and Rifampin;
  • if you have suffered or still suffer from bladder cancer, diabetic retinopathy or kidney or liver disease in the past ;
  • if you are pregnant or breastfeeding .

Surgeons and dentists should be informed of ongoing Pioglitazone therapies . In case of infections, fever, diseases, increased stress or trauma, you should inform your doctor, as it may be necessary to vary the dosage of Pioglitazone.

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