The Nimesulide is used in the short-term treatment of acute pain in case of acute pain related to gynecological disorders, as in dysmenorrhea , and in the case of osteoarthritis , cancer pain and acute attacks of gout .
How does Nimesulide work?
The Nimesulide belongs to the pharmacological therapeutic group of anti-inflammatory / non-steroidal antirheumatic drugs, so-called NSAIDs, as it is a sulfanilide . Nimesulide inhibits the functions of white blood cells (leukocytes) , which increase in number during any inflammatory state. It also inhibits the synthesis of Prostaglandins , or of those substances with many functions produced by the body and endowed with pro-inflammatory, algogenic and pyrogenic action .
How is Nimesulide administered?
Nimesulide must be taken rectally in the form of a suppository , or it can be taken orally in the form of granules or tablets .
Side effects of Nimesulide
The use of Nimesulide for short periods of time and with adequate dosages is normally tolerated very well. However, the use of Nimesulide can lead to several adverse effects. In the majority of cases, these occurred on patients who underwent excessively prolonged treatments or on particularly predisposed subjects:
- central ailments: drowsiness, headache , insomnia, dizziness
- cardiovascular reactions: tachycardia, hypertension
- gastrointestinal disorders: epigastric pain, nausea , vomiting, diarrhea
- urogenital disorders: dysuria , oliguria
- allergic skin reactions ( rash , pruritus , urticaria , edema) and respiratory reactions ( asthma , dyspnoea , bronchospasm)
- hematological and liver function changes
Contraindications and warnings on the use of Nimesulide
The treatment based on Nimesulide must be of short duration , as it is only indicated to overcome the inflammatory states and / or acute pain. In any case, the intake of Nimesulide should be limited to the shortest possible time.
The subjects with subjects with liver, kidney or gastrointestinal problems must undergo an intense monitoring of the therapy and of potential undesirable effects, whenever it is necessary to administer this NSAID. Monitoring should be performed by the attending physician.
The use of Nimesulide is contraindicated during the entire course of pregnancy as it acts by decreasing the number of prostaglandins which, among their various functions, also have that of allowing the correct development of the embryo and fetus. Research on the safety of NSAIDs in pregnancy has shown how NSAIDs can significantly increase the risk of malformations affecting the unborn child’s respiratory and cardiovascular systems.
The interactions between Nimesulide and other drugs that must be kept in mind are: anticoagulant drugs , given the risk of bleeding already associated with the use of Nimesulide; drugs capable of altering gastric motility which can give rise to variations, even important ones, in the absorption of Nimesulide; opioid analgesic drugs , which can increase the analgesic effect. Finally, Nimesulide can increase its renal toxicity if taken together with most diuretics