High Androstenedione Levels In Females Symptoms.Androstenedione is a steroid hormone belonging to the androgen group . It is also known as andro , andros or 4-androstenedione . The human body can synthesize this compound in various glands, although it can also be found in meat and some plants.
High Androstenedione Levels In Females Symptoms
The main structure responsible for the production of this hormone is the cortex of the adrenal gland. The gonads also participate in its synthesis, so it is possible to find high concentrations in the testes and ovaries. This substance originates from cholesterol, which must undergo a series of enzymatic changes to transform into the compound.
Androstenedione is a precursor steroid hormone that can be converted into testosterone and estrone, a form of estrogen. Elevated androstenedione levels in females can be suggestive of an underlying condition and may be associated with a range of symptoms. It is important to note that while high androstenedione levels might correlate with these symptoms, they are not diagnostic on their own. A comprehensive clinical evaluation is necessary to establish a cause and appropriate treatment.
Some symptoms and signs that can be associated with high androstenedione levels in females include:
- Hirsutism: Excessive hair growth in areas where men typically grow hair, such as the face, chest, and back.
- Acne: Especially if it’s severe or sudden onset.
- Oily skin: Increased oil production can lead to acne and oily skin.
- Irregular or absent menstrual periods: Elevated androstenedione can disrupt the menstrual cycle.
- Infertility: Issues with ovulation can arise due to imbalanced hormone levels.
- Scalp hair thinning or male-pattern baldness: This is due to the conversion of androstenedione to a form of testosterone.
- Deepening of the voice: A symptom that is less common but can be seen with prolonged and significant elevations.
- Increased muscle mass: Another less common symptom.
- Clitoral enlargement: Seen in extreme cases.
- Decreased breast size: A potential effect of the imbalance in estrogen and androgen levels.
High androstenedione levels might be seen in conditions such as:
- Polycystic ovary syndrome (PCOS): A common endocrine disorder that affects women of reproductive age. It’s characterized by irregular periods, high levels of androgens (including androstenedione), and polycystic ovaries seen on ultrasound.
- Congenital adrenal hyperplasia (CAH): A genetic disorder that results in impaired cortisol production, leading to an overproduction of androgens.
- Adrenal tumors or ovarian tumors: Rarely, tumors in these glands can lead to an overproduction of androstenedione.
- Cushing’s syndrome: Although this primarily involves overproduction of cortisol, there can be an overproduction of androstenedione as well.
If someone suspects they have high androstenedione levels or is showing any of the symptoms mentioned, it’s crucial to consult with a healthcare professional. They can provide a diagnosis and guide the appropriate course of action.
