Estriol (Ovestrion)

Estriol is a female sex hormone used to relieve vaginal symptoms related to the lack of the female hormone estriol.Estriol can be purchased from conventional pharmacies, under the tradename Ovestrion, in the form of vaginal cream or tablets.

Estriol indications

Estriol is indicated for itch-related female hormone replacement and vaginal irritation caused by the lack of female estriol hormone.

Directions for use of Estriol

The use of Estriol varies according to the presentation and the problem to be treated, and the general guidelines are:

Vaginal cream

  • Genitourinary tract atrophy:1 application per day for the first few weeks, reduced according to symptom relief until maintenance dose of 2 applications per week is reached;
  • Before or after menopause vaginal surgery:1 application per day 2 weeks before surgery and 1 application 2 times per week for 2 weeks after surgery;
  • Diagnosis in case of cervical smear:1 application every other day for 1 week before collection.

Oral pills

  • Atrophy of genitourinary tract:4 to 8 mg daily for the first few weeks, followed by gradual reduction;
  • Before or after vaginal menopausal surgery:4 to 8 mg per day 2 weeks before surgery and 1 to 2 mg per day for 2 weeks after surgery;
  • Diagnosis in case of cervical smear:2 to 4 mg per day for 1 week before collection;
  • Infertility due to cervical hostility:1 to 2 mg from the 6th to 18th day of the menstrual cycle.

In either case, the dose of Estriol should be adequate as directed by the gynecologist.

Estriol Side Effects

Major side effects of estriol include vomiting, headaches, cramps, breast tenderness, and itchiness or local irritation.

Estriol Contraindications

Estriol is contraindicated for pregnant women or women with undiagnosed vaginal bleeding, history of otosclerosis, breast cancer, malignant tumors, endometrial hyperplasia, venous thromboembolism, arterial thromboembolic disease, acute liver disease, porphyria, or hypersensitivity to any of the components of the formula.

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