What are bioflavonoids and where do they come from?

Vitamin C and bioflavonoids normally occur together in nature. Bioflavonoids are involved in the absorption and use of vitamin C, being especially important for the good condition of blood vessels, since they support the integrity of collagen. Some bioflavonoids have antioxidant properties quite similar to those of vitamin C, and invitro has been shown to protect vitamin C and adrenaline from oxidation by copper-containing enzymes.

Bioflavonoids contain a wide range of antioxidant molecules that experts consider to be cardioprotective, neuroprotective, venotonic, and anti-free radicals. If you want to know in what foods these natural wonders are hidden and if it has been possible to concentrate them in pill form, be sure to read this new article. You’ll love it!

Contents[Hide]

• 1weekly newsletter on nutrition and supplements
• 2The most important
• 3The best bioflavonoid supplements on the market: our recommendations
  • 1The favorite of online users
  • 2The best bioflavonoid supplement for circulation
  • 3The best tolerated bioflavonoid supplement
  • 4Athletes’ favorite
  • 5The best value for money
• 4Buying Guide: What You Should Know About Bioflavonoids
  • 1What are bioflavonoids?
  • 2What are bioflavonoid supplements for?
  • 3Are bioflavonoid supplements beneficial for circulation?
  • 4Is it possible to improve the appearance of the skin using bioflavonoid supplements?
  • 5How to use bioflavonoid supplements?
  • 6Is supplementation with bioflavonoids safe?
• 5Purchase criteria
  • 1Dietary restrictions
  • 2Subclasses and synergism
  • 3Administration format
  • 4Conservation and expiration
  • 5Organic farming
  • 6Value for money
• 6Summary

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The most important

• Bioflavonoids are antioxidant molecules of plant origin.
• Bioflavonoid supplements may improve symptoms of varicose veins and hemorrhoids.
• When buying a bioflavonoid supplement, we must pay attention to our diet, the type of flavonoid included in the product, its form of administration and the expiration date.

The best bioflavonoid supplements on the market: our recommendations

After carefully studying the online market , we have designed this list with the five best bioflavonoid supplements currently available. These products stand out among the others for the satisfaction of their users, for their attractive value for money or for their perfectly adjusted dose. You will not be disappointed.

• The favorite of online users
• The best bioflavonoid supplement for circulation
• The best tolerated bioflavonoid supplement
• Athletes’ favorite
• The best value for money

The favorite of online users

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Solgar Citrus Bioflavonoids Complex Tablets – Package of 100Read user reviews

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This product contains 100 bioflavonoid tablets from citrus. Its high dose (1000 mg) ensures a powerful action, although it could be indigestible for the most delicate people.

More than 100 positive opinions endorse this supplement, capable of improving the hearing and circulation of people who use it regularly.

The best bioflavonoid supplement for circulation

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Country Life, Gluten Free, Routine – 500mg x100tabsRead user reviews

37.95 EUR

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This supplement has been designed with the aim of improving the vascular health of its users. It contains 500 mg of the routine bioflavonoid and is suitable for celiacs.

People who use this article claim to be very satisfied. This bioflavonoid relieves the symptoms of hemorrhoids, greatly improving the quality of life for buyers.

The best tolerated bioflavonoid supplement

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CITRUS BIOFLAVONOIDS – 100 capsRead user reviews

11,90 EUR

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Gastrointestinal complaints are the main side effect associated with taking bioflavonoid supplements. This article includes a moderate amount of antioxidants, being effective without being indigestible.

Consumers give this product a good rating, which improves circulation without causing adverse effects.

Athletes’ favorite

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HSN Vitamin C 1000mg | 4 Month Supply | With Citrus Bioflavonoids + Rosehip | Antioxidant, Collagen Production, Iron Absorption | Vegan, Gluten Free, Lactose Free, 120 TabletsRead user reviews

12,90 EUR

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This combination of bioflavonoids, vitamin C and rosehip oil is intended to promote the formation of new collagen fibers, keeping body tissues elastic.

Users, mostly athletes, feel less fatigued after using this product, recovering before their workouts.

The best value for money

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Vitamin C, 1000 mg + Bioflavonoids – Released by Time, 100 Vegan TabletsRead user reviews

9.99 EUR

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Ingredient combinations are typically priced higher. However, this vitamin C and bioflavonoid supplement has an outstanding price-performance ratio.

Most of your buyers compliment this item. It is delivered in record time and the tablets taste good.

Buying Guide: What You Should Know About Bioflavonoids

The term “bioflavonoid” encompasses a very large number of antioxidant molecules of plant origin. Their potential cardioprotective effects have put them in the sights of numerous researchers, who have found in them a possible solution for the most annoying symptoms of venous insufficiency.

Bioflavonoids have antioxidant actions.
(Source: Adamowicz: 93271232 / 123rf.com)

What are bioflavonoids?

Bioflavonoids (or flavonoids) are molecules of plant origin. They are the product of the metabolism of different plant species, which they provide with a characteristic flavor and color. These compounds also provide fruits and vegetables with a defense against bacterial, fungal and environmental attacks. Flavonoids encompass different substances, such as ( 1 ) :

• Flavonols: They are synthesized in response to solar radiation. They abound in fruits and vegetables.
• Flavones: Celery, parsley, and citrus peel are the richest foods in flavones. Diosmin, also known as venosmin, is a flavone widely used for the treatment of venous pathology.
• Flavanones: These bioflavonoids are found in high concentrations in albedo, the “soft side” of citrus fruits such as orange and grapefruit. They can also be found in other fresh fruits and vegetables.
• Isoflavones: These molecules have a structure similar to that of female estrogens (which is why they are also known as phytoestrogens). They are found in soy.
• Anthocyanidins: These compounds are highly appreciated independently for their antioxidant function. We can find them in fruits and vegetables, especially in the grape.
• Flavanols: In turn, these compounds are divided into catechins, procyanidins and proanthocyanidins . These molecules oppose the action of free radicals and are abundant in products such as tea, wine, and chocolate.

The above classification is simplified. It is possible to divide the previous categories into more limited groups according to the molecular structure of these substances. However, flavonoids are equal in their functions. In general, these compounds are considered antioxidants and anti-inflammatories capable of maintaining normal cardiovascular health ( 2 ) .

Thus, bioflavonoids have antioxidant, anti-inflammatory and anti-angiogenic functions (preventing the formation of new blood vessels when this can be harmful. For example, during tumor growth). The following table summarizes the main types (and subtypes) of bioflavonoids and their main food sources ( 3 ) :

What are bioflavonoid supplements for?

A varied diet, including fresh fruits and vegetables and even small “transgressions” such as chocolate, will be able to provide us with a good amount of bioflavonoids that protect us from inflammation and oxidation. Although a recommended daily amount (CDR) of flavonoids has not been defined, the possible consequences of its deficit in the diet are known:

• Capillary fragility bruises
• Pain in the extremities
• Muscular weakness
• Leg muscle cramps

Furthermore, increased inflammation and oxidation could worsen cardiovascular health and lead to accelerated aging. The people most at risk of bioflavonoid deficiency are those who are under stress, follow a diet rich in processed products, or have unhealthy habits, such as tobacco use.

Experts agree that the consumption of bioflavonoids through the diet should be prioritized. However, if it is not possible to transform our habits or if we want a little “push” while we reform our diet, we can use a supplement. Thus, the consumption of flavonoids could provide us with the following benefits ( 3 ) :

• Neuroprotection: It has been observed that bioflavonoids can prevent the destruction of certain enzymes necessary for the transmission of brain impulses. Although these data have been obtained thanks to in vitro experimentation (in a test tube), they could indicate a possible protective action of the normal neuronal function of bioflavonoids.
• Anti-inflammation: Bioflavonoids hinder the production of molecules related to inflammation. These molecules have been used successfully in various human clinical trials, proving effective in alleviating pain caused by inflammatory pathologies such as chronic pancreatitis ( 4 ) .
• Antibacterial action: Plants synthesize bioflavonoids to defend themselves against the aggressions of different pathogens. Furthermore, these molecules appear to be capable of inhibiting resistance to Escherichia coli and Staphylococcus aureus antibiotics , two pathogenic species responsible for countless human infections.
• Cardioprotection: Flavonoids could combat the deleterious effects of diabetes, protect the structure of blood vessels and reduce blood pressure in obese people.
• Antioxidation: Bioflavonoids are capable of neutralizing free radicals, cellular metabolism wastes (and products of pollution and stress) that have been linked to accelerated aging and diseases such as cancer, although these products cannot be ensured to prevent the appearance of neoplasms ( 5 ) .

Vegetables, fruits, wine, and tea are rich in bioflavonoids.
(Source: Yelenayemchuk: 53694254 / 123rf.com)

Are bioflavonoid supplements beneficial for circulation?

Bioflavonoids are often used to treat complications of venous insufficiency, and can be classified as venotonic agents . According to the Cochrane Library, routine bioflavonoid has been shown to be effective in alleviating the following symptoms resulting from poor circulation in the lower limbs ( 6 ) :

• Edema (increased fluid)
• Leg cramps
• Feeling of heaviness
• Swelling
• Paresthesias (strange and uncomfortable sensations)

Although the Cochrane Library confirms that routine supplementation has a moderate venotonic potential, it indicates that further studies will be necessary to more precisely delimit the influence of this flavonoid on circulation (for example, classifying patients in order of severity of their insufficient venous).

Bioflavonoids have also been proposed as a possible remedy for hemorrhoids. These venous dilations can intensely affect the quality of life of those affected, preventing proper evacuation of the intestines, causing bleeding and discomfort. According to the Cochrane Library, bioflavonoids are moderately effective for their treatment ( 7 ) :

Bioflavonoids studied: Quercetin, rutin, hesperidin and diosmin.

Populations studied: Men and women between 30 and 50 years old. One study included pregnant women. Some studies included patients recovering from previous hemorrhoid surgery.

Positive effects:

• Pain relief
• Decreased need for pain relievers (Naproxen and Tramadol)
• Decreased bleeding from non-operated hemorrhoids
• Decreased bleeding after hemorrhoid surgery
• Reduction of itching associated with hemorrhoids
• Better control of leakage or leakage of intestinal content
• Subjective feeling of improvement and well-being

Adverse effects: Mild gastrointestinal discomfort

In conclusion, bioflavonoids can improve symptoms of venous insufficiency and hemorrhoids. These supplements are not a substitute for medical treatment, and should be consumed only after the approval of a health worker. The Ministry of Health does not recommend routine use for a period longer than 2-3 months.

Bioflavonoids can improve the elasticity of the skin.
(Source: Maneerat: 87788874 / 123rf.com)

Is it possible to improve the appearance of the skin using bioflavonoid supplements?

There are numerous data that corroborate that the inclusion of antioxidant compounds in the diet (in the form of bioflavonoids, vitamin E and vitamin A, among others) can improve the appearance of the skin, preserving its elasticity and preventing and even partially reversing the damage caused by sun exposure (photoaging) ( 8 , 9 , 10 ) .

In general, studies that include bioflavonoids combine them with other substances, so it cannot be guaranteed that the observed effect is entirely due to the action of these antioxidants. However, we have found four studies that do use flavonoids exclusively. We have summarized their results in the following table:

We note that bioflavonoid supplements, applied topically or ingested in capsule form, could potentially improve skin tone and elasticity. Its positive influence on purple lesions (purplish spots that appear as a result of age or in relation to other diseases) is especially encouraging.

And, nevertheless, it must be taken into account that the fact that these studies have been carried out in animals or in a limited number of human subjects, with little explicit or variable doses, reduces the reliability of some trials on the other hand, very ambitious. It is possible that in a short time we can confirm the real effect of these substances!

How to use bioflavonoid supplements?

A recommended dose for bioflavonoid supplementation has not been defined, making it difficult to develop a treatment plan. After reviewing the available literature on these antioxidants, we have created a plan that you can follow, keeping in mind that the manufacturer’s instructions and your doctor’s orders will always take priority:

• Dose? To minimize the risk of the appearance of adverse effects, it is recommended to use the minimum effective dose. The doses used range between 50 and 250 mg, formulations having higher doses (up to 1000 mg) but that are related to an increased prevalence of side effects ( 14 , 15 ) .
• When? The supplement can be taken in a single daily dose or divided into two doses. If you are going to take amounts greater than 50 mg and the format of your supplement allows it, it is better to divide the dose to avoid the appearance of gastrointestinal discomfort.
• Foods? We have found no information for or against co-administration of bioflavonoid food and supplements. People with delicate stomachs could take them with meals to avoid stomach pain.

After one or two months of treatment the positive effects of supplementation should be observed (improvement of the appearance of the skin and improvement of symptoms of venous insufficiency and hemorrhoids). Currently, the Ministry of Health does not recommend taking bioflavonoids continuously for more than two months, so it will be necessary to take “breaks” ( 6 ) .

Is bioflavonoid supplementation safe?

Many people wonder if bioflavonoids are a safe supplement, fearing that these items are bad allies of health in the medium and long term. After reviewing the available data, we have concluded that flavonoid supplements are safe items, as long as they are used according to the manufacturer’s instructions ( 15 ) :

• Overdose: No immediate side effects have been reported from excessive bioflavonoid consumption. However, it does not recommend exceeding the recommended dose.
• Pregnancy and lactation: Although bioflavonoids have been used in pregnant women for the treatment of hemorrhoids, supplementation with these articles is not recommended unless under the supervision of a healthcare professional.
• Children under 18 years of age: Children should not be supplemented with bioflavonoids. A possible relationship has been found between the use of nutritional supplements with bioflavonoids and the appearance of childhood leukemia ( 16 ) .
• Drug interactions: Bioflavonoid supplements can interact with blood thinning drugs, such as warfarin. These people (and also those individuals who are under chronic treatment with antihypertensives, antidiabetics and chemotherapy) should consult a health professional before starting supplementation.
• Side effects: The adverse effects related to taking bioflavonoid supplements are, generally, gastrointestinal complaints (nausea, pain and heavy digestion) that can be mild or moderate, forcing the withdrawal of supplementation in some specific cases ( 7 ) .

Some studies with venotonic substances found that long-term use of these compounds can cause, in rare cases, a condition called agranulocytosis. This disease, considered serious, is characterized by a decrease in white blood cells that leaves the body defenseless against infections.

This serious side effect has put bioflavonoids in the spotlight and has forced the Ministry of Health to restrict their continued use to a period of less than two months, at which time you should “rest” and consult a professional if the symptoms we wanted to treat have not disappeared ( 6 ) .

Diabetics can benefit from the use of bioflavonoids.
(Source: Haurylik: 37375525 / 123rf.com)

Purchase criteria

There are countless supplementation items that include small amounts of bioflavonoids among their ingredients. However, if what you are interested in is a product that contains a quantity of potent and unadulterated flavonoids, we advise you to make your purchase taking into account the criteria that we present in the following lines:

• Dietary restrictions
• Subclasses and synergism
• Administration format
• Conservation and expiration
• Ecological agriculture
• Price-performance ratio

Dietary restrictions

Most bioflavonoid supplements have been made from plant ingredients and are suitable for vegans. If you are celiac, watch out for items that get their antioxidants from wheat, an ingredient widely used in the manufacture of flavonoid supplements that, unfortunately, contain gluten.

The consumption of bioflavonoid supplements for a period of more than two months is not recommended.
(Source: Thai: 97705353 / 123rf.com)

Subclasses and synergism

Routine bioflavonoids, hesperidin, diosmin, and quercetin have been shown to be most effective in improving circulation and skin tone, so we recommend that you choose products that contain at least one of these molecules. Citrus-based supplements tend to contain rutin and quercetin, being an optimal choice.

A common additive in bioflavonoid supplements is vitamin C. Many supplement manufacturers insist that ascorbic acid and flavonoids act synergistically, although there is no evidence to support this claim. You could choose these combo items if you also want to enjoy the benefits of vitamin C.

Administration format

The most common form of administration for bioflavonoid supplements are capsules and tablets. However, you can also find these preparations in the form of syrup if you have difficulty swallowing the tablets. If you are a fan of skincare, you can also use flavonoids in the form of a gel or cream.

For years, bioflavonoids were considered a type of vitamin (vitamin P) with effects similar to those of ascorbic acid or vitamin C. (Source: Rostislavsedlacek: 81939952 / 123rf.com)

Conservation and expiration

We do not recommend using bioflavonoids after their expiration date, as these antioxidant molecules will gradually lose their free anti-radical capacity. Keep your flavonoid supplement in a cool, dry place, protected from light and extreme temperatures, avoiding contact with toxic substances.

Ecological agriculture

Pesticides have been found in some bioflavonoid supplements. For this reason, we advise you to choose brands that use ingredients from organic farming, free of substances harmful to our health. If you are concerned about the environment, also choose a supplement in recyclable packaging that allows you to consume responsibly.

Bioflavonoids may improve symptoms of venous insufficiency.
(Source: Zlikovec: 34729475 / 123rf.com)

Price-performance ratio

The price of bioflavonoid supplements fluctuates dramatically, and you can find very cheap items (for less than ten euros) and other high-end products (over 30 euros). If you want to save, stick to supplements that contain a moderate dose of bioflavonoids (50 mg) and that do not contain other ingredients.

Summary

Bioflavonoid supplements are underestimated by many people, replacing them with more commercial and striking substances, such as collagen or vitamins. Paradoxically, these fabulous antioxidants could improve the quality of life of those fans of supplementation who know how to get the most out of their venoprotective potential .

Yes, your skin will be smoother and healthier after completing a bioflavonoid supplementation treatment. But the true benefit could be found below, where these antioxidants will improve the symptoms of varicose veins and hemorrhoids, causing symptomatic relief that will restore your quality of life. Don’t miss out on trying bioflavonoids!