What is Ketoconazole used for?

The Ketoconazole is an antifungal imidazole . It works by slowing down the growth of fungi that can cause infections in the body.

What is Ketoconazole used for?

Ketoconazole is used to treat mycoses ( fungal infections) when no other drugs are available or when the medicines that could be used are not tolerated by the patient.

It is also used to treat Cushing’s syndrome and advanced prostate cancer , but there are still doubts about its safety and effectiveness in this type of treatment. In these cases, the drug is taken in large quantities.

How is Ketoconazole taken?

Ketoconazole is taken orally in the form of tablets, typically once a day. If necessary, the doctor may increase the dose.

More than 6 months of treatment may be needed to defeat the infection .

Side effects of Ketoconazole

Possible side effects of Ketoconazole include:

  • redness
  • dry mouth
  • chills
  • heartburn
  • changes in the color of the tongue
  • constipation
  • diarrhea
  • difficulty falling asleep or staying asleep
  • muscle pain
  • nose bleeding
  • numbness, burning or tingling in hands or feet
  • stomach ache
  • headache
  • in men, increased breasts
  • nervousness
  • hair loss
  • gas production
  • reduction in the number of spermatozoa, especially if taken in high doses
  • reduced sexual capacity
  • sensitivity to light
  • changes in the perception of taste

It is important to contact a doctor immediately in case of:

  • breathing difficulties or difficulty swallowing
  • swelling of the eyes, face, lips, tongue, hands, feet, ankles or calves
  • urticaria
  • itch
  • rash
  • hoarseness
  • tiredness or weakness

Side effects and warnings on the use of Ketoconazole

Ketoconazole should not be used to treat fungal meningitis or nail fungus . Furthermore, it should only be used when other medicines cannot be used, if they are not available or not tolerated by the patient.

Ketoconazole can damage the liver . For this reason it should not be taken together with alcoholic beverages, which can increase its side effects. Also, since it can alter your heart rhythm, it should not be taken together with disopyramide, dofetilide, dronedrone, pimozide, quinidine, cisapride, methadone or ranolazine.

Any aluminum, calcium or magnesium based antacids should be taken 1 hour before or 2 hours after Ketoconazole.

Before taking the drug it is good to inform your doctor:

  • in case of allergy to Ketoconazole, its excipients or other medicines;
  • other medicines, phytotherapics and supplements taken, in particular Alprazolam, Eplerenone, Ergot alkaloids, Felodipina, Irinotecan, Lovastatina, Lurasidone, Midazolam, Nisoldipina, Simvastatin, Tolvaptan, Triazolam, Aliskiren, Anticoagulant, Openspitant, Apitantan , Buspirone, Carbamazepine, Calcium Antagonists, Cancer Drugs, Busulfan, Dasatinib, Docetaxel, Erlotinib, Ixabepilone, Lapatinib, Nilotinib, Paclitaxel, Trimetrexato, Vincristine, Vinblastine, Vinorelbine, Ciclesonide, Cilostazol, Cinacetone, Cinacetone, Cinacetone , Fentanyl, Fesoterodine, Fluticasone, Haloperidol, drugs against HIV, Immunosuppressants, Imatinib, drugs against erectile dysfunction, against bad digestion, heartburn, ulcer or Tuberculosis, Nadolol, Oxycodone,Phenytoin, Praziquantel, Quetiapina, Ramelteon, Repaglinide, Risperidone, Salmeterol, Saxagliptin, Solifenacin, Tamsulosin, Telithromycin, Tolterodine;
  • if you are pregnant or breastfeeding ;
  • in case of adrenal insufficiency .

It is important to inform surgeons or dentists about ongoing Ketoconazole therapies.

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