The Gentamicin is a broad-spectrum antibiotic of the family of the aminoglycosides.It is able to attack a wide range of bacteria. Through the external cell wall of the bacterium,it reaches the cytoplasmic environment As a result, it also blocks its metabolic and structural activity .
What is Gentamicin used for?
Gentamicin is indicated in the therapeutic treatment of infections such as neonatal sepsis, septicemia and the most serious ones caused by staphylococci and Gram-negative bacteria, such as Pseudomonas Aeruginosa and enterobacteria (it is particularly active on Klebsiella and Serratia). It is also used in the treatment and prevention of endocarditis from streptococci, enterococci and staphylococci . The ointment is used for the treatment of infectious or high risk of infection skin diseases.
How is Gentamicin taken?
Gentamicin is marketed in the form of tablets for oral use , solution for injections intramuscularly and intravenously and in the form of ointment to be applied to the skin.
Side effects of Gentamicin
Like all aminoglycoside antibiotics, Gentamicin can cause irreversible ototoxicity (injury of the acoustic nerves), especially following systemic treatment: particular attention should be paid to the administration of Gentamicin in patients with auditory-vestibular pathologies.
Gentamicin can also be toxic to the kidneys : particular caution is recommended in patients with kidney and skeletal muscle diseases .
Antibiotics must always be used on prescription and strictly following the doses and methods indicated by the doctor . Failure to do so could reduce the absorption of the drug or render treatment unnecessary or, furthermore, increase the resistance of the bacterium to the drug.
Contraindications and warnings of Gentamicin
Recent studies have highlighted the ability of Gentamicin to cause damage to the fetus’ auditory system : for this reason, the use of this drug is generally contraindicated during pregnancy , and is also not recommended in the subsequent breastfeeding period.