This Research Article has been supervised by Nutritionist/Food Expert Anum Nazir).She is Lecturer in School of Nutritional sciences At University of Faisalabad).

Researcher And Writer

Dua Ali

Supervised By Anum  Nazir 

Department of Nutritional Sciences

University Of Faisalabad,Pakistan.

Topic:Effects of Vitamin E and Vitamin C in Cancer

Abstract

Recent studies in the scientific literature suggest that several vitamins such as vitamin E might be a effective option for the treatment or at least prevention of the spread of cancer. However ironically many research focused on α‐tocopherol,. The main and important focus of this approach is the understanding of the mechanisms regulated by vitamin E and their action in case of cancer apoptosis.

Supplementation of antioxidant vitamins has been associated with reduced risk of cancers such as stomach cancer or reoccurrence of pancreatic cancer and lesions in several countries in Asia such as China and Colombia.

Introduction

Some scientific studies also prove that consumption of vitamin Eor vitamin C supplements, both significant antioxidants, may decrease the risk of bladder cancer. In a carefully concluded report by the the World Cancer Research Fund, it has been founded that 30–40% of cancers are mainly connected to nutrition

Mainly there is a direct connection between occurance of cancer and poor nutrition, multiple studies are currently underway to find out and isolate important chemopreventive agents from natural nutritional sources. It was stated that these antioxidants have positive and assisting effect rather than primary and direct effects on cancer prevention.

• Vitamin E deficiency is not very common, it doesn’t really occur that easily however some people are more likely to get the deficiency than other individuals such as Infants, people with fat digestion problems are more likely to have vitamin E deficiency.

• Different signs like nerve damage are indicators that there might be a deficiency of this vitamin

• It is a fat-soluble nutrient, it functions mainly as an antioxidant, and protects cells from damage of the factors called free radicals.

In addition to providing cell protection, vitamin E is vital to a functioning immune system. As a powerful antioxidant, it helps cells fight off infection.

• Objective

• To determine wheather or not Vitmain C and E have anticancer effects of and how exactly they act upon different body cells to find out the exact operational effect of these antioxidants on cancer cells if any

Methods

• Prospective cohort of 77,721 men and women aged 50–76 years from Washington State in the (Vitamins And Lifestyle) study. etalI-Min Lee, MBBS, ScD; Nancy R. Cook, ScD; Michael Gaziano, MD

• Research and studies were studied through the Seattle–Puget Sound SEER. I-Min Lee, MBBS, ScD; Nancy Cook, ScD; J. Michael Gaziano, MD

• Supplemens of many multivitamins, such as vitamin C, vitamin E, and folate were seen not decreasing the risk of lung cancerScott M. Lippman, MD; Eric A. Klein, MD; Phyllis J. Goodman, MS; et al

• Supplements of Vitamin E synthetic were seen to be causing risks of Lung cancer. Crossref
• Theodore M. Brasky, Roberta M. Ray, Sandi L. Navarro, Jeannette M. Schenk, Alison M. Newton, Marian L. Neuhouser. (2020) Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women’s Health Initiative. International Journal of Cancer 110.
• Adrian F. Gombart, Adeline Pierre, Silvia Maggini. (2020) A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients 12:1, 236
• However, among current smokers and recent quitters, those who consumed at least 100 IU of supplemental vitamin E per day had a RR of 0.44 (95% CI, 0.18–1.07) for metastatic or fatal prostate cancer compared with nonusers. Christopher G.Slatore ¹, Alyson J. Littman ^2,3, David H. Au ^1,4, Jessie A. Satia ⁵, and Emily White ^2,6

Result

• Several studies stated that Vitamin C and E does cause significant improvement in quality of health and have secondary effects but they do not cause significant primary prevention from cancers like Prostate cancer peptic cancer etc.

References

• Yumie Takata, Xiao-Ou Shu, Maciej S. Buchowski, Heather M. Munro, Wanqing Wen, Mark D. Steinwandel, Margaret K. Hargreaves, William J. Blot, Qiuyin Cai. (2020) Food intake of folate, folic acid and other B vitamins with lung cancer risk in a low-income population in the Southeastern United States. European Journal of Nutrition 59:2, 671-683.

Tengfei Mao, Lei Yang, Guoqiang Liu, Yen Wei, Yanzi Gou, Jun Wang, Lei Tao. (2019) Ferrocene-Containing Polymer via the Biginelli Reaction for In Vivo Treatment of Oxidative Stress Damage. ACS Macro Letters 8:6, 639-645.

Online publication date: 23-May-2019

• E White, J S Shannon and R E Patterson
• June M. Chan, Meir J. Stampfer, Jing Ma, Eric B. Rimm, Walter C. Willett and Edward L. Giovannucci