What Is Toxic Amblyopia In Neuropathy;Pathogenesis And Treatment

Toxic amblyopia (nutritional amblyopia) is also called retrobulbar optic neuropathy which is damage of optic nerve.A remarkably uni­form and stereotyped disorder of vision is encoun­tered occasionally in persons who are chronically undernourished. Characteristically it evolves slowly and subacutely, the mode of onset of symp­toms being much the same from patient to pa­tient. Visual impairment usually starts insidi­ously and reaches a maximum in several weeks to months. Blurred or dim vision, difficulty in reading, photophobia, and retrobulbar discom­fort on moving the eyes are the common present­ing complaints.

On examination, the patient has bilaterally symmetrical central, centrocecal, or paracentral scotoma. Ophthalmoscopic changes are restricted at first to slight redness of the temporal margins of the optic discs; minimal pallor is observed at a later stage. Often, no ab­normality is visible. The peripheral visual fields are usually intact. The visual disorder is, to a large extent, reversible with improvement of nutrition.

Pathology. The pathologic change in nutri­tional amblyopia consists of bilaterally sym­metrical loss of myelinated fibers in the central parts of the optic nerves, chiasm, and optic tracts, corresponding in location to the papillomacular bundle. In severe cases, the retina loses macular ganglion cells, probably secondary to the “zonal” destruction of medullated fibers in the retrobulbar parts of the optic nerve.

Pathogenesis of Toxic Amblyopia.

This type of visual disturbance has been encountered in undernourished popula­tions all over the world. It is commonly seen during famine, and among civilian and military prisoners of war: It is endemic in certain parts of Africa, Asia, and South America. Among the more privileged populations in the western world, the syndrome is seen in persons chronically addicted to alcohol or, occasionally, to tobacco, who neglect their nutrition. A similar syndrome also occurs as a complication of vitamin B12 deficiency and dia­betes mellitus, as well as in patients treated with isoniazid for tuberculosis.

This visual disorder accompanies other neurologic syndromes believed to have a nutritional cause, such as Strachans syndrome, in which amblyopia is combined with paresthesias of the feet, hands, trunk, and, occa­sionally, face, loss of reflexes, dizziness, deafness, hoarseness, spasticity, ataxia, and a variety of mucocutaneous lesions (genital dermatitis, corneal degeneration, glossitis, arid stomatitis). In the chronic alcoholic patient, amblyopia may occur in conjunction with Wernicke’s disease, cerebellar degeneration, Marchiafava-Bignami disease, and peripheral neuropathy.

In recent years, a nutritional deficiency rather than a toxicity has been held responsible for so-called tobacco-alcohol amblyopia. Detailed clinical and pathologic studies fail to distinguish this type of amblyopia from nutritional amblyopia. In clinical experi­ments, patients with amblyopia continued their usual consumption of alcohol and tobacco, but ate an adequate diet supplemented by B vitamins. All showed some recovery of visual acuity and a reduc­tion in the size of the scotoma.

As yet, the me­tabolic aberration or specific vitamin deficiency responsible for the development of amblyopia has not been defined. A lack of vitamin B12, thiamin, riboflavin, and pyridoxine or a failure in the de­toxification of cyanide present in tobacco smoke, have been implicated in the genesis of the syn­drome.

Except for isolated ‘findings of reduced serum vitamin B12 levels, the abnormal urinary excretion of methylmalonic acid arid low levels of blood transketolase activity, no specific biochem­ical abnormalities have been reported in cases of amblyopia.

Toxic Amblyopia Treatment Guidelines.

 Treatment with oral or parenteral B vitamins and improved nutrition are usually followed by improvement, depending upon the severity of the amblyopia and its duration before therapy is instituted.

by Abdullah Sam
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