How does Adefovir work?

It is used to treat chronic hepatitis B virus infections (chronic hepatitis B) .

How does Adefovir work?

Exerts its action by slowing the growth of the hepatitis B virus.

How is Adefovir administered?

Adefovir is administered orally in the form of tablets.

What are the side effects of Adefovir?

Treatment with this medicine can be associated with the appearance of viral strains resistant to its action. Therapy can also lead to the accumulation of lactic acid in the blood , serious liver problems and, especially in the case of predisposition, serious kidney problems. In some cases, discontinuation of administration has been associated with serious worsening of hepatitis, while in case of HIV co- infection it can lead to the appearance of treatment-resistant strains of the human immunodeficiency virus, especially if you are not aware of the co-infection or if not being treated.

Other possible side effects include:

  • discharge of diarrhea;
  • bloating;
  • headache;
  • indigestion;
  • slight stomach pain:
  • feeling sick;
  • gastric discomfort;
  • retching;
  • feeling of weakness.

It is important to seek medical attention immediately in case of:

  • skin rash ;
  • urticaria ;
  • itching ;
  • difficulty breathing;
  • feeling of heaviness or tightness in the chest;
  • swelling of the mouth, face, lips or tongue;
  • worsening of symptoms;
  • reduced response to treatment;
  • bone pain ;
  • severe or persistent nausea or vomiting;
  • severe or persistent sleepiness;
  • severe pain in the stomach or back (with or without nausea or vomiting);
  • shortness of breath;
  • indolence;
  • dark urine, loss of appetite, pale stools, severe stomach pain, jaundice ;
  • muscle cramps or pain;
  • unusual tiredness or weakness;
  • changes in the amount of urine produced;
  • dizziness or light-headedness;
  • accelerated breathing;
  • fast or irregular heartbeat;
  • unusual feeling of cold (especially if on arms or legs).

Contraindications and warnings on the use of Adefovir

It can be contraindicated in case of enlarged liver, lactic acidosis or taking Tenofovir- based medicines .

Before taking it is important to tell your doctor:

  • about the presence of any allergies to the active substance , to its excipients, to any other drug, to foods or other substances;
  • medicines, phytotherapy and supplements already taken in the past, in particular nucleoside analogues or drugs that could damage the kidneys;
  • in case of resistance of HBV infection to treatment with lamivudine;
  • if you suffer (or have suffered previously) from kidney or liver problems, abnormal liver function tests, lactic acidosis, high blood pressure, diabetes or HIV infection;
  • in case of liver transplants;
  • in case of risk of HIV infection;
  • in case of severe overweight;
  • in the case of pregnant women or breastfeeding women.

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