Acute respiratory viral infections or ARVI are the most common infectious diseases. On average, an adult gets ARVI two to four times a year. Antiviral drugs are prescribed for a speedy recovery. In this article, we will talk in more detail about a substance such as enisamium iodide, which is the active ingredient of Nobazit® Forte: what is this active substance, does it have any contraindications, and in what cases is it most effective.
Trade name 1
Nobazit® Forte.
Dosage form 1
Film-coated tablets.
Compound
Active ingredient: enisamium iodide (N-methyl-4-benzylcarbamidopyridinium iodide) – 500.0 mg. 1
Action
In order for the flu or ARVI virus to begin to multiply and cause the development of the disease, it needs to get inside the cell. Nobazit® Forte — enisamium iodide, an antiviral agent, an isonicotinic acid derivative — effectively suppresses the action of flu viruses and other pathogens of acute respiratory viral infections (ARVI) due to its direct influence on the process of penetration of viruses through the cell membrane. 1,2
After oral administration, enisamium iodide quickly enters the bloodstream. The maximum concentration of the active substance in the blood is observed 2–2.5 hours after taking the drug. The half-life is 13.5–14 hours. Enisamium iodide is metabolized in the liver, but is quickly eliminated from tissues (the half-life is 2–3 hours). It is excreted from the body by 90–95% in the urine in the form of metabolites. 1
Nobazit® Forte helps to increase the body’s resistance to viral infections. Reduces acute clinical manifestations of viral intoxication, helps to reduce the duration of the disease. 1
In addition to the antiviral effect, Nobazit® Forte has anti-inflammatory, analgesic and antipyretic effects. 2,3 The anti-inflammatory effect of the substance has been proven in a study published in the scientific journal Therapeutic Archives. 3
Spectrum of antiviral activity
Clinical trial data confirm that enisamium iodide can be used as an etiotropic therapy for acute respiratory viral infections caused by various pathogens, including influenza viruses A and B, respiratory syncytial virus, human metapneumovirus, parainfluenza virus , coronaviruses, rhinoviruses, and adenoviruses . 4.5
Indications 1
NOBAZIT ® FORTE is used to treat influenza and other acute respiratory viral infections, including as part of complex therapy in patients aged 12 years and over.
Contraindications 1
Contraindications include:
● Hypersensitivity to enisamium iodide or any of the additional components of the drug.
● Pregnancy, breastfeeding period.
● Children under 12 years of age.
● The presence of allergic reactions regardless of the nature of the allergen in the anamnesis.
● Severe organic damage to the liver and kidneys.
● Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
● Sucrase/isomaltase deficiency, fructose intolerance.
Special instructions 1
Nobazit® Forte should be used with caution in patients with thyroid disease, especially hyperthyroidism.
Method of administration and dosage 1
The drug is taken orally after meals, without chewing.
Adults are prescribed 500 mg three times a day. Children over 12 years old – 250 mg three times a day. The recommended course of treatment is 5 to 7 days.
For complete information on the method of administration and dosage regimen, see the Instructions for Medical Use of Nobazit® Forte.
Side effect 1
The following side effects may occur:
● hypersensitivity reactions;
● dryness and bitter taste in the mouth;
● swelling of the oral mucosa;
● hypersalivation (drooling);
● yellowing of the tongue;
● nausea, vomiting;
● heartburn, abdominal pain;
● heaviness in the right hypochondrium;
● diarrhea, bloating;
● shortness of breath;
● throat irritation.
For full information on side effects, see the Instructions for Medical Use of Nobazit® Forte.
Overdose 1
In case of overdose, the side effects described in the relevant section may increase. If they occur, the patient undergoes gastric lavage and symptomatic treatment.
Interaction with other drugs 1
Enisamium iodide enhances the action of antibacterial and immunomodulatory agents. A combination with ascorbic acid and other vitamins is advisable. The drug can also be prescribed simultaneously with the use of recombinant interferon.
For complete information on interactions with other drugs, see the Instructions for Medical Use of Nobazit® Forte
Efficiency
Enisamium iodide has a complex effect in the fight against the virus:
● prevents the virus from entering the cell;
● alleviates symptoms of acute respiratory viral infections;
● helps to reduce the duration of the disease;
● increases the body’s resistance to viral infections. 1
Due to its proven effectiveness, Nobazit® Forte is included in the clinical recommendations of the Russian Ministry of Health for the treatment of influenza and acute respiratory viral infections. 6.7
Briefly about the main thing
➢ Nobazit® Forte is an antiviral agent with a broad spectrum of action.
➢ Used to treat influenza and acute respiratory viral infections in patients aged 12 years and over.
➢ Nobazit® Forte helps reduce symptoms of intoxication, shorten the duration of acute respiratory viral infections and increase antiviral immunity.
➢ Available in the form of film-coated tablets for oral administration.
➢ Nobazit® Forte is prescribed to patients aged 12 years and over, 1 tablet 3 times a day for 5–7 days.
➢ Nobazit® Forte is included in the clinical recommendations of the Ministry of Health of the Russian Federation for the treatment of acute respiratory viral infections and influenza in adults.
➢ The drug can be found in pharmacies in your city.
