Bioinorganic Chemistry . It is the branch of Chemistry that studies the biological role of metals. It includes the study of both natural phenomena and the behavior of metalloproteins, as well as artificially introduced metals, including those that are non-essential elements, in medicine and toxicology .
Summary
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- 1 Description
- 2 History
- 3 See also
- 4 Source
Description
Many biological processes, such as respiration, depend on molecules that fall within the field of study of inorganic chemistry. This discipline also includes the study of inorganic or mimetic models that mimic the behavior of metalloproteins.
As a mixture of biochemistry and inorganic chemistry, bioinorganic chemistry is important in the study of the involvement of metal transport proteins, substrate binding and activation, chemistry of the transfer of atoms and functional groups, as well as the properties of metals in biological chemistry .
History
Paul Ehrlich used organoarsenics for the treatment of syphilis , thus demonstrating the relevance of metals (although Arsenic is a metalloid ) in medicine, which reached the full acceptance of the scientific community when Rosenberg discovered the anticancer activity of cisplatin (cis-PtCl 2 (NH 3 ) 2 ).
The first protein that was crystallized was urease , which was later found to contain Nickel at its active site. [[Vitamin B1 2 ]] was crystallographically shown by Dorothy Crowfoot Hodgkin , it consists of a cobalt ion in oxidation state +3 coordinated to a corrin ring.
The DNA structure proposed by Watson and Crick, demonstrated the structural role played by phosphate- containing polymers .
