What is Labetalol used for?

It is an antihypertensive medicine that works by blocking two types of receptors simultaneously, alpha- and beta-adrenergic. By obstructing the first at the level of the small arteries, it minimizes the resistance to blood flow , whereas the inhibition of beta-receptors minimizes the side effects of vasodilation at the cardiac level.

Taken together, these two actions reduce and regulate blood pressure.

What is Labetalol used for?

Labetalol is used in the presence of hypertension (even in pregnancy) and after a myocardial infarction .It can also be used in the presence of hypertensive crisis and to treat hypotension during general anesthesia.

How is Labetalol taken?

The Labetalol takes in the form of tablets in a first dose of 100 mg 2 times a day (morning and evening), always after eating. Thereafter, and if necessary, the dosage can be increased up to 200 mg 2 times a day. However, it cannot be excluded that in especially resistant situations two doses of 400 mg per day should be taken.

The maximum dose that can be taken is 2.4 total grams per day.

Side effects of Labetalol

Among the possible side effects of Labetalol we also find:

  • changes in the composition of the blood
  • angioedema
  • asthenia
  • increase in liver function tests
  • bradycardia
  • bronchospasm
  • nasal congestion
  • liver damage
  • depression
  • dyspnoea
  • cardiac conduction problems
  • urination problems
  • vision problems
  • epigastric pain
  • malleolar edema
  • hepatitis
  • rashes
  • lichenoid eruptions
  • temperature
  • tingling in the scalp
  • postural hypotension
  • jaundice
  • lethargy
  • systemic lupus eritematosus
  • headache
  • ejaculation failure
  • toxic myopathy
  • nausea
  • liver necrosis
  • antibody nucleus positivity
  • itch
  • rash
  • acute urinary retention
  • dryness of the nasal mucosa
  • dryness and eye irritation
  • vivid dreams
  • sweats
  • tremors
  • dizziness
  • He retched

Contraindications and warnings associated with the use of Labetalol

Labetalol must never be taken in the presence of:

  • diabetic acidosis
  • feeding time
  • second or third degree atrioventricular block
  • severe marked bradycardia
  • heart failure resistant to digitalis therapy
  • severe kidney failure
  • hypersensitivity to the active substance or to the excipients of the medicine (including lactose)
  • cardiogenic shock and other conditions associated with severe and prolonged hypotension

You must also be careful and have specific precautions in the presence of:

  • asthma and bronchospasm
  • liver damage
  • heart failure

Among the medicines with which it can interact we also find:

  • calcium channel blockers of the verapamil type
  • class I antiarrhythmics
  • amiodarone
  • anesthetics
  • tricyclic antidepressants
  • cimetidine

Finally, by causing dizziness and lethargy, Labetalol must be taken with caution when driving or operating dangerous machinery.

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