Acetylsalicylic acid is a derivative of salicylic acid dell’acetilato with anti-inflammatory properties, analgesic and antipyretic properties . Its anti-inflammatory action is due to the inhibition mechanism of the synthesis of prostaglandins, mediators of the inflammatory process. From a strictly biochemical point of view, it carries out its action by acetylating the terminal amino group of the cyclooxygenase subunit of the enzyme prostaglandin synthetase and thus inhibiting the activity of the enzyme and therefore the biosynthesis of prostaglandins.
What is Acetylsalicylic Acid used for?
It is used in the treatment of minor pains ( toothache , migraine, myalgias, dysmenorrhea). It is also used in the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis and in the symptomatic treatment of febrile states and flu or cooling syndromes.
How is Acetylsalicylic Acid taken?
It is marketed in the form of tablets, effervescent tablets and suspension for oral use and in the form of injectable preparations.
Side effects of Acetylsalicylic Acid
Its intake can lead to various side effects that can manifest themselves in a more or less severe way based on the individual predisposition of the individual subject and based on the dosage and duration of therapy.
In general, however, the use of this active ingredient can cause intestinal disorders , such as:
- feeling sick
- constipation (constipation)
- stomach ache
- bleeding (in severe cases)
- pancytopenia (numerical decrease in all figured blood elements)
- loss of blood clotting ability
Disorders of the genital and urinary tract
- deterioration of renal function
- changes mainly in the carbohydrate metabolism
- feeling sleepy
- confusion and tremors
- greater risk of cerebro and cardiovascular events
- bullous reactions in severe cases
- gnarled erythema
- skin rash
- hearing loss
Contraindications and warnings associated with the use of Acetylsalicylic Acid
It is severely contraindicated both during pregnancy and during breastfeeding. The use of this drug is also not recommended in subjects with peptic ulcer, intestinal bleeding, ulcerative colitis, angioedema, Crohn’s disease or previous history for the same pathologies, concomitant anticoagulant therapy, liver and kidney failure and asthma.The medicine is also not recommended for children under 12 years of age.