This Research Article has been supervised by Nutritionist/Food Expert Anum Nazir).She is Lecturer in School of Nutritional sciences At University of Faisalabad).

Researcher And Writer


Supervised By Anum  Nazir 

Department of Nutritional Sciences

University Of Faisalabad,Pakistan





In this review article there’s effect of aloe Vera gel on eczema either it’s positive or negative and eczema is a skin disease which causes skin soreness, redness, itching, tissue damage and inflammation. Eczema don’t have a single specific clinical feature it has many factors and is difficult to differentiate but is painful and majorly have 2 factors which are internal and external factors and parameters. Eczema can be genetic because of mutation in genes or because of family history. It can also be because of environmental factors like exposure or frequent exposure to chemicals, heavy metals and detergents. If someone is hypersensitive or already suffering from a skin condition or disease and have low immunity or a weak immune system can have mild to severe eczema. Eczema can appear at any surface of skin most common on hands, at the back of knees and on back. Aloe Vera is a medicinal plant used from ancient times and still widely used all around the world. Its chemical composition is very special helps in healing and soothing effects. It consist of its stem, stem covering and gel also known as extract which is used in many situations and is beneficial for humans. It is known as magical plant in medicinal field to treat


skim diseases like ECZEMA, vitiligo and psoriasis. Aloe Vera has positive effects in patients of different ages suffering from eczema.




Eczema is one of the most common skin inflammatory disease in children as well as adults. In this skin become itchy, skin sores, pains when come in contact, skin damage and sleeplessness. There’s a need of special clothes and ointments to apply. (C Hoare et al., 2000)


Eczema and atopic dermatitis are recognized as major health problems worldwide. Presence estimates are one-third of the community. (Hanifin et al., 2007)


Eczema is a disease in which there is no specific clinical lesions. Signs and symptoms changes according to the age of the patient and the position and place of the eczema either on hand or on body. Eczema don’t have specific clinical assessment signs and pathogenesis and it is multifactorial disease that’s why not a specific cure and different cure and guidelines have for different patients. The causes of eczema are multi factorial and are complex but there are 2 main factors EXTERNAL and INTERNAL.


External Factors of Eczema: External factors include the environmental parameters and the internal factors include the genetic parameters and mutations. Some non-specific irritants like use of detergents, exposure to cold water and low temperature can cause edema. Being hypersensitive and having sensitive skin or suffering from autoimmunity and burns are the major risk factors of eczema. Infections by a bacteria STAPHYLOCOCCUS can cause eczema because it can easily make colonies on the skin and damage the tissue. Different allergens, chemical substances and microbes can also cause eczema. Heavy metals like nickel and chromium can cause allergic reactions on skin and then can turn into eczema. Staphylococcus aureus can cause eczematous reactions on skin not because of its allergic powers but also the promotion of other skin allergens.


Clinical Symptoms:


Symptoms of eczema can appear at any time during a life of a patient but mostly symptoms appear in childhood specially for having a genetic history of eczema. Signs and symptoms usually appear in the popliteal area and skin becomes dry, inflamed and there’s itching. Eczema


is more severe if it starts to happen in the first six months of age. Nickle sensitivity is also a reason of eczema. Dry skin is most often seen in patients of eczema Characterized by rough and scaly skin. Roughness causes the irregular skin pattern (T.ruzicka et al., 2013)


Aloe Vera: (Common Name: Barbados Aloe, Family, and Xanthorrhoeaceae).


Many medicinal plants are used to treat skin diseases such as eczema, psoriasis, vitiligo, Applying of some traditional herbs is a widespread practice in different regions of the world. It is majorly prevalent in villages where medical services are less available. Herbal treatments are generally thought as more effective and have less side effects. Herbal clinical and medical research opens new therapeutic options. Eczema is considered as a cluster of medical situations that causes the skin to appear inflamed and irritated. The treatment for eczema is complicated. Aloe Vera is used for the cure of eczema. Skin is the largest organ in human body. It forms the first defense line. Its three layers are:


  • Epidermis


  • Dermis


  • Subcutaneous Layer


Each layer has a special role in the maintenance of skin. They are different in thickness all over the body and individually. Aloe Vera is commonly found in arid areas. It is local in Africa but it has also been cultivated all over the world. It is a stemless plant growing up to 60 to 100 cm tall. Its flowers are produced in summer and are pendulous with yellow flowers. It is watery, thick and have bright yellow flowers, viscous and fleshy, 30 to 50 cm long, pea-green leaves. The leaf edge is serrated and spiky (Zari et al., 2015)




  1. To check the effect of aloe Vera gel on eczema patients


  1. To check is there any positive effect of aloe Vera gel on patients with atopic eczema


  1. Know about eczema


  1. Know about the medicinal properties of aloe Vera gel




Aloe Vera has various phytochemicals and have different biological specialties that improves health and prevent from different disease conditions. It is the richest natural source of health for humans. Its composition has revealed the presence of more than 200 different biologically active components. Many biological properties linked with Aloe Vera are contributed by the inner gel of the leaves. The Aloe Vera has more than 400 species used worldwide. Aloe Vera has many properties like anti-inflammatory factors and antioxidant factors, antimicrobial effects, anti-cancerous agent’s immune boosters and hypoglycemic effects. It is used traditionally to treat many diseases. It is applied externally for wound healing, soothing inflamed skin and ECZEMA. Because of its soothing effect, the skin becomes softer and smooth. And wounds heal more fastly and rapidly. Many patients said that there is a decrease in the symptoms of eczema such as skin dryness, scaling and improved skin quality. Its anti-bacterial activities prevent infection.




Positive Effect:


Aloe Vera gel was compared with the placebo in 60 patients having light to severe eczema. The cure rate was 83% with aloe Vera gel as compared to 7% with placebo. A. Vera is used in traditional medicine as a different beneficial skin treatment. Its gel is used for external treatment of minor wounds and inflammatory skin disorders, minor skin irritations including burns, bruises and abrasions. It’s recommended to apply freshly extracted gel because of sensitivity to enzymatic activity, oxidative and microbial degradation. The aloe Vera gel have such properties that are harmful to many bacteria and fungi. A cream containing 0.5% aloe for 4 weeks lessened the skin “plaques” linked with psoriasis. (Zari et al., 2015).


Different Beneficial Effects:


Aloe Vera, is the treatment of many inflammatory skin conditions like eczema. Atopic eczema is an inflammatory skin disease. A double-blind, randomized, placebo-controlled prospective clinical trial was performed in 44 adult patients with atopic eczema. Comparison of symptoms score chart in the Aloe Vera groups and placebo groups, prior and after the treatment showed a major decrease in scariness, intense itching and the number of sites, redness and lesions involved in atopic eczema, but not in erythema. Worldwide improvement rates of patients treated


with Aloe Vera were significantly more than in placebo-treated patients, as assessed by dermatologists. (Da vardy et al., 2009).


Effects of Aloe Vera Gel on Atopic Eczema:


An 8-week, study of the clinical medicinal importance of aloe Vera gel was done in a group of 6 to 12-year-old children with atopic eczema. Patients were admitted if they presented the criteria of atopic dermatitis established by Hanifin and Rajka. Symptoms in aloe Vera gel treated children were minimized more rapidly than in the other control group receiving only placebo. During the 8 weeks of the study, scores showed a statistically major fall in erythema and other cutaneous symptoms in the aloe Vera gel group. The children’s parents did not observe any side effects during the study. The results of this preliminary study suggest that aloe Vera gel can effectively control itching and other cutaneous symptoms in children suffering from atopic eczema without noticeable side effects. (La rosa et al., 1994)


Comparison of Aloe Vera Gel With Ointment on Eczema Patients:


Comparison of the effects of Aloe Vera and chamomile ointment on the severity and intensity of Eczema in infants. Clinical trial contains, 90 children of less than 2 years, who had eczema and were hospitalized were included in the study. The infants were separated into equal groups, with group receiving routine treatments and the other receiving chamomile and Aloe Vera ointment thrice a day. The samples were examined on the first, third, and sixth day. The data were analyzed by descriptive and analytical tests in SPSS software version 22.0. Not much difference was seen but all the groups achieve recovery fast. (G.badelbuu et al., 2019).


Skin Diseases and Aloe Vera:


In humans, aloe Vera gel has been witnessed to increase the healing from deep scrapes, frostbite, sun burns, flash burns of the skin layers, and even canker sores. Only a single study has had opposite effect that is, aloe Vera treated surgical wounds healing by secondary intention took longer to heal than comparison wounds. Aloe Vera gel has often used as a topical treatment for burn wounds and eczema. A study of 27 adults with partial thickness burns and eczema those treated with aloe Vera gel healed early of an average of six days rapidly than those applied with Vaseline gauze. Psoriasis remedy In a 1995 double-blind, placebo controlled study of aloe’s effect on 60 patients with psoriasis vulgaris, an aloe Vera extract (0.5%) in a hydrophilic cream


resulted in a significant clearing of the psoriatic plaques in 83.3% of the aloe Vera gel treated patients versus 6.6% of the placebo group . The aloe treatment was tolerated with no adverse drug related side effects on skin or on the body. Its soothing and cooling property is the treatment of dry skin associated with exposure to allergens there aloe Vera gel gloves enhanced the skin healing capacity, minimize the appearance of fine wrinkles and decrease erythema (M. Moghaddasi et al., 2011).


Aloe Vera gel is majorly used in the treatment of disturbances, especially skin diseases. The wound-healing effects have been attributed to its moisturizing and anti-inflammatory effects as well as its beneficial effect on the maturation of collagen. (Finberg et al., 2015)



Conclusion from the review of literature of different past researches and studies of the effect of aloe Vera gel on eczema is positive aloe Vera has anti-inflammatory and soothing properties which helps in reducing the inflammation, soreness and skin damage. Aloe Vera gel has cooling effect so it also reduces the eczema related redness and heat on the skin.




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MJ Finberg, GL Muntingh, CEJ van Rensburg – Inflammopharmacology, 2015 – Springer MR La, C Ranno, I Musarra, F Guglielmo… – Annals of …, 1994 – europepmc.org

S Ghanipour Badelbuu, Y Javadzadeh… – … Journal of Pediatrics, 2019 – eprints.mums.ac.ir


S Ghanipour Badelbuu, Y Javadzadeh… – … Journal of Pediatrics, 2019 – eprints.mums.ac.ir


ST Zari, TA Zari – J Med Plants Res, 2015 – researchgate.net


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