Doxycycline has been used to treat bacterial infection for more than 50 years. New findings indicate that this antibiotic may have a new application: treating Parkinson’s disease .
This disease is caused by abnormal accumulation and toxicity of the alpha-synuclein protein. In cell culture, the scientists observed that the formation of alpha-synuclein aggregates is reduced by 80% in the presence of doxycycline. Models of rats with Parkinson’s disease fed the doxycycline-added diet improved their symptoms. Tests on humans with low doses of doxycycline are starting now.